{"title":"通过最小表面双单元连续过渡连接策略设计生物医学梯度多孔支架","authors":"Yuting Lv, Zheng Shi, Binghao Wang, Miao Luo, Ouyang Xing, Jia Liu, Hao Dong, Yanlei Sun, Liqiang Wang","doi":"10.36922/ijb.1263","DOIUrl":null,"url":null,"abstract":"In this work, a series of new gradient porous scaffolds were innovatively designed via a dual-unit continuous transition connection strategy based on the minimal surface structures (primitive [P], diamond [D], and gyroid [G]). The scaffolds were successfully prepared through selective laser melting technology. The results showed that the dual-unit continuous transition connection strategy significantly improved the mechanical properties of the connected scaffolds. The compression strength of the scaffolds was found to be (P-G)>(P-D)>(G-P)>(G-D)>(D-G)>(D-P), with the P-G structure exhibiting a compression strength of 167.7 MPa and an elastic modulus of 3.3 GPa. The mechanical properties of the porous scaffolds were primarily influenced by the outer unit type, the connection condition between different units, the unit size, and the porosity. Scaffolds with the outer P unit demonstrated better mechanical properties due to the higher mechanical strength of the P structure. The connection performance between different units varied, with P and G units forming a good continuous transition connection, while the connection performance between P and D units was the weakest. The dual-unit continuous transition connection strategy offers a promising approach to optimize the connection performance of different units, providing new insights into the design of medical porous scaffolds.","PeriodicalId":48522,"journal":{"name":"International Journal of Bioprinting","volume":null,"pages":null},"PeriodicalIF":6.8000,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design of biomedical gradient porous scaffold via a minimal surface dual-unit continuous transition connection strategy\",\"authors\":\"Yuting Lv, Zheng Shi, Binghao Wang, Miao Luo, Ouyang Xing, Jia Liu, Hao Dong, Yanlei Sun, Liqiang Wang\",\"doi\":\"10.36922/ijb.1263\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this work, a series of new gradient porous scaffolds were innovatively designed via a dual-unit continuous transition connection strategy based on the minimal surface structures (primitive [P], diamond [D], and gyroid [G]). The scaffolds were successfully prepared through selective laser melting technology. The results showed that the dual-unit continuous transition connection strategy significantly improved the mechanical properties of the connected scaffolds. The compression strength of the scaffolds was found to be (P-G)>(P-D)>(G-P)>(G-D)>(D-G)>(D-P), with the P-G structure exhibiting a compression strength of 167.7 MPa and an elastic modulus of 3.3 GPa. The mechanical properties of the porous scaffolds were primarily influenced by the outer unit type, the connection condition between different units, the unit size, and the porosity. Scaffolds with the outer P unit demonstrated better mechanical properties due to the higher mechanical strength of the P structure. The connection performance between different units varied, with P and G units forming a good continuous transition connection, while the connection performance between P and D units was the weakest. The dual-unit continuous transition connection strategy offers a promising approach to optimize the connection performance of different units, providing new insights into the design of medical porous scaffolds.\",\"PeriodicalId\":48522,\"journal\":{\"name\":\"International Journal of Bioprinting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2024-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Bioprinting\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.36922/ijb.1263\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Bioprinting","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.36922/ijb.1263","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
摘要
本研究基于最小表面结构(原始结构[P]、菱形结构[D]和陀螺结构[G]),通过双单元连续过渡连接策略,创新性地设计了一系列新型梯度多孔支架。通过选择性激光熔融技术成功制备了支架。结果表明,双单元连续过渡连接策略显著提高了连接支架的力学性能。支架的压缩强度依次为(P-G)>(P-D)>(G-P)>(G-D)>(D-G)>(D-P),其中 P-G 结构的压缩强度为 167.7 MPa,弹性模量为 3.3 GPa。多孔支架的力学性能主要受外单元类型、不同单元之间的连接条件、单元尺寸和孔隙率的影响。由于 P 结构的机械强度较高,外层为 P 单元的支架具有更好的机械性能。不同单元之间的连接性能各不相同,P 单元和 G 单元形成了良好的连续过渡连接,而 P 单元和 D 单元之间的连接性能最弱。双单元连续过渡连接策略为优化不同单元的连接性能提供了一种可行的方法,为医用多孔支架的设计提供了新的思路。
Design of biomedical gradient porous scaffold via a minimal surface dual-unit continuous transition connection strategy
In this work, a series of new gradient porous scaffolds were innovatively designed via a dual-unit continuous transition connection strategy based on the minimal surface structures (primitive [P], diamond [D], and gyroid [G]). The scaffolds were successfully prepared through selective laser melting technology. The results showed that the dual-unit continuous transition connection strategy significantly improved the mechanical properties of the connected scaffolds. The compression strength of the scaffolds was found to be (P-G)>(P-D)>(G-P)>(G-D)>(D-G)>(D-P), with the P-G structure exhibiting a compression strength of 167.7 MPa and an elastic modulus of 3.3 GPa. The mechanical properties of the porous scaffolds were primarily influenced by the outer unit type, the connection condition between different units, the unit size, and the porosity. Scaffolds with the outer P unit demonstrated better mechanical properties due to the higher mechanical strength of the P structure. The connection performance between different units varied, with P and G units forming a good continuous transition connection, while the connection performance between P and D units was the weakest. The dual-unit continuous transition connection strategy offers a promising approach to optimize the connection performance of different units, providing new insights into the design of medical porous scaffolds.
期刊介绍:
The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.