用计算机辅助药物设计方法设计出提取自吲哚啉-2-酮的新小分子,作为有效的 TRKs 抑制剂

Rachid Haloui, Khaoula Mkhayar, Ossama Daoui, Kaouakeb El Khattabi, Abdelmoula El abbouchi, Samir Chtita, Souad Elkhattabi
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引用次数: 0

摘要

肌球蛋白受体激酶(TRKs)是与神经营养性酪氨酸激酶受体基因融合相关的癌症的罪魁祸首,已被确定为抗癌药物的有效靶点。
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Design of new small molecules derived from indolin-2-one as potent TRKs inhibitors using a computer-aided drug design approach
Tropomyosin receptor kinase (TRKs) enzymes are responsible for cancers associated with the neurotrophic tyrosine kinase receptor gene fusion and are identified as effective targets for anticancer d...
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