外泌体在口腔疾病进展中的新作用。

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE International Journal of Oral Science Pub Date : 2024-01-15 DOI:10.1038/s41368-023-00274-9
Jiayi Wang, Junjun Jing, Chenchen Zhou, Yi Fan
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引用次数: 0

摘要

牙周炎、唾液腺疾病和口腔癌等口腔疾病对患者的消化功能、发音和审美要求产生了不利影响,极大地挑战了患者的健康状况。延迟诊断和非针对性治疗深刻影响着患者的预后和生活质量。探索早期检测和精确治疗的创新方法是口腔医学的一个前景广阔的前沿领域。外泌体是一种纳米级的细胞外囊泡,几乎所有类型的细胞都会分泌外泌体。随着研究的不断深入,这些源于细胞内的细胞外囊泡在生物过程中的复杂作用逐渐展现出来。外泌体作为有价值的诊断和治疗工具备受关注,因为它们能够转移丰富的生物载体,并在多种细胞功能中发挥错综复杂的作用。在这篇综述中,我们概述了外泌体在口腔疾病领域的最新应用,重点关注与炎症相关的骨病和口腔鳞状细胞癌。我们描述了外泌体改变的特征,并展示了它们作为早期诊断生物标记物的潜在应用,强调了它们在多种口腔疾病中作为指标的作用。我们还总结了外泌体在靶向治疗中的应用前景,并提出了将外泌体用于临床治疗的未来方向。
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Emerging roles of exosomes in oral diseases progression.

Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine. Exosomes, which are characterized as nanometer-sized extracellular vesicles, are secreted by virtually all types of cells. As the research continues, the complex roles of these intracellular-derived extracellular vesicles in biological processes have gradually unfolded. Exosomes have attracted attention as valuable diagnostic and therapeutic tools for their ability to transfer abundant biological cargos and their intricate involvement in multiple cellular functions. In this review, we provide an overview of the recent applications of exosomes within the field of oral diseases, focusing on inflammation-related bone diseases and oral squamous cell carcinomas. We characterize the exosome alterations and demonstrate their potential applications as biomarkers for early diagnosis, highlighting their roles as indicators in multiple oral diseases. We also summarize the promising applications of exosomes in targeted therapy and proposed future directions for the use of exosomes in clinical treatment.

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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
期刊最新文献
Organoids in the oral and maxillofacial region: present and future. Personalized bioceramic grafts for craniomaxillofacial bone regeneration An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches. CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B.
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