电子烟和尼古丁贴片作为孕期戒烟辅助工具的安全性：电子烟和贴片妊娠试验（PREP）随机对照试验的二次分析。

IF 5.2 1区医学 Q1 PSYCHIATRY Addiction Pub Date : 2024-01-17 DOI:10.1111/add.16422

Francesca Pesola, Katie Myers Smith, Anna Phillips-Waller, Dunja Przulj, Christopher Griffiths, Robert Walton, Hayden McRobbie, Tim Coleman, Sarah Lewis, Rachel Whitemore, Miranda Clark, Michael Ussher, Lesley Sinclair, Emily Seager, Sue Cooper, Linda Bauld, Felix Naughton, Peter Sasieni, Isaac Manyonda, Peter Hajek

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引用次数: 0

摘要

目的：本研究旨在探讨电子烟（EC）和尼古丁贴片（NRT）用于帮助怀孕吸烟者戒烟的安全性：最近一项关于电子烟与尼古丁贴片的试验报告了随机试验组的安全性结果。我们根据产品使用情况进行了进一步分析：英格兰的 23 家医院和苏格兰的一家戒烟服务机构参与了这项研究：干预措施：干预措施：我们对怀孕期间定期使用和未使用EC和NRT的妇女进行了比较：测量指标包括与基线相比的尼古丁摄入量、出生体重、其他妊娠结局、不良事件、孕产妇呼吸道症状以及早期戒烟者的复吸情况：使用电子烟比使用 NRT 更为普遍（47.3% 对 21.6%，P 结论）：吸烟孕妇定期使用电子烟或尼古丁贴片似乎与任何不良后果无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial

Aims

The aim of this study was to examine the safety of e-cigarettes (EC) and nicotine patches (NRT) when used to help pregnant smokers quit.

Design

A recent trial of EC versus NRT reported safety outcomes in the randomized arms. We conducted a further analysis based on product use.

Setting

Twenty-three hospitals in England and a stop-smoking service in Scotland took part.

Participants

The participants comprised 1140 pregnant smokers.

Interventions

We compared women using and not using EC and NRT regularly during pregnancy.

Measurements

Measurements included nicotine intake compared with baseline, birth weight, other pregnancy outcomes, adverse events, maternal respiratory symptoms and relapse in early abstainers.

Findings

Use of EC was more common than use of NRT (47.3% vs 21.6%, P < 0.001). Women who stopped smoking (abstainers) and used EC at the end-of-pregnancy (EOP) reduced their salivary cotinine by 45% [49.3 ng/ml, 95% confidence interval (CI) = −79.8 to −10]. Only one abstainer used NRT at EOP. In dual users, cotinine increased by 19% (24 ng/ml, 95% CI = 3.5–68). In women reporting a reduction of at least 50% in cigarette consumption, cotinine levels increased by 10% in those using nicotine products and by 9% in those who did not. Birth weights in dual users and exclusive smokers were the same (3.1 kg). Birth weight in abstainers using either nicotine product was higher than in smokers [3.3 kg, standard deviation (SD) = 0.7] versus 3.1 kg, SD = 0.6; difference = 0.15 kg, 95% CI = 0.05–0.25) and not different from abstainers not using nicotine products (3.1 kg, SD = 0.8). Abstainers and smokers using nicotine products had no worse pregnancy outcomes or more adverse events than abstainers and smokers not using them. EC users reported more improvements than non-users in cough [adjusted relative risk (aRR) = 0.59, 95% CI = 0.37–0.93] and phlegm (aRR = 0.53, 95% CI = 0.31–0.92), controlling for smoking status. EC or NRT use had no association with relapse.

Conclusions

Regular use of e-cigarettes or nicotine patches by pregnant smokers does not appear to be associated with any adverse outcomes.

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.