胶原蛋白样氧化低密度脂蛋白受体-1(LOX-1)在炎症和病原体相关相互作用中的作用。

IF 4.7 3区 医学 Q2 IMMUNOLOGY Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-01-17 DOI:10.1159/000535793
Sarah Truthe, Tilman E Klassert, Stefan Schmelz, Danny Jonigk, Wulf Blankenfeldt, Hortense Slevogt
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引用次数: 0

摘要

背景:众所周知,凝集素样氧化低密度脂蛋白受体-1(LOX-1)是氧化低密度脂蛋白(oxLDL)的主要受体,在动脉粥样硬化的形成过程中起着重要作用。最近的研究表明,它还与癌症、缺血性中风和糖尿病有关。LOX-1 是一种 C 型凝集素受体,参与激活免疫细胞和炎症过程。摘要:这篇综述汇编了目前关于 LOX-1 在炎症过程和宿主与病原体相互作用中的潜在影响的知识,特别强调了它在免疫反应中的调节作用。还讨论了不同物种 LOX-1 同源物的基因组和结构变异,以及从不同细胞类型和器官特异性相互作用的角度探讨了 LOX-1 在炎症过程中的潜在作用:本文介绍的结果揭示了人类和鼠类 LOX-1 既相似又不同的结构,并为不同相互作用模式的可能起源提供了线索。这些描述引起了人们对其适用性的关注,特别是小鼠模型的适用性。进一步的研究还应旨在更好地了解 LOX-1 与不同病原体之间大部分未知的结合和相互作用机制。这不仅能加深我们对 LOX-1 参与炎症过程的理解,还能为免疫调节方法确定潜在的靶点。
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Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions.

Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent research has shown its involvement in cancer, ischemic stroke, and diabetes. LOX-1 is a C-type lectin receptor and is involved in the activation of immune cells and inflammatory processes. It may further interact with pathogens, suggesting a role in infections or the host's response.

Summary: This review compiles the current knowledge of potential implications of LOX-1 in inflammatory processes and in host-pathogen interactions with a particular emphasis on its regulatory role in immune responses. Also discussed are genomic and structural variations found in LOX-1 homologs across different species as well as potential involvements of LOX-1 in inflammatory processes from the angle of different cell types and organ-specific interactions.

Key messages: The results presented reveal both similar and different structures in human and murine LOX-1 and provide clues as to the possible origins of different modes of interaction. These descriptions raise concerns about the suitability, particularly of mouse models, that are often used in the analysis of its functionality in humans. Further research should also aim to better understand the mostly unknown binding and interaction mechanisms between LOX-1 and different pathogens. This pursuit will not only enhance our understanding of LOX-1 involvement in inflammatory processes but also identify potential targets for immunomodulatory approaches.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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