Manuel Bernabeu , Elena Cabello-Yeves , Eduard Flores , Anna Samarra , Joanna Kimberley Summers , Alberto Marina , M Carmen Collado
{"title":"生命早期抗菌药耐药性基因的纵向和横向微生物传播的作用：从母婴双亲中获得的启示","authors":"Manuel Bernabeu , Elena Cabello-Yeves , Eduard Flores , Anna Samarra , Joanna Kimberley Summers , Alberto Marina , M Carmen Collado","doi":"10.1016/j.mib.2023.102424","DOIUrl":null,"url":null,"abstract":"<div><p>Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother–infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"77 ","pages":"Article 102424"},"PeriodicalIF":5.9000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527423001613/pdfft?md5=a000753455adb97cbb6a28bf09d139d1&pid=1-s2.0-S1369527423001613-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads\",\"authors\":\"Manuel Bernabeu , Elena Cabello-Yeves , Eduard Flores , Anna Samarra , Joanna Kimberley Summers , Alberto Marina , M Carmen Collado\",\"doi\":\"10.1016/j.mib.2023.102424\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother–infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area.</p></div>\",\"PeriodicalId\":10921,\"journal\":{\"name\":\"Current opinion in microbiology\",\"volume\":\"77 \",\"pages\":\"Article 102424\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2024-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1369527423001613/pdfft?md5=a000753455adb97cbb6a28bf09d139d1&pid=1-s2.0-S1369527423001613-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1369527423001613\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in microbiology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369527423001613","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads
Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother–infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area.
期刊介绍：
Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year:
Host-microbe interactions: bacteria
Cell regulation
Environmental microbiology
Host-microbe interactions: fungi/parasites/viruses
Antimicrobials
Microbial systems biology
Growth and development: eukaryotes/prokaryotes
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