[皮肤病毒组:从病毒学到个性化医疗]。

IF 0.7 4区 医学 Q4 VIROLOGY Virologie Pub Date : 2023-12-01 DOI:10.1684/vir.2023.1028
Clément Dominguez-Lafage, Marta Laganà, Franck Gesbert, Viviana Marin-Esteban, Géraldine Schlecht-Louf, Françoise Bachelerie, Claire Deback
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引用次数: 0

摘要

皮肤病毒群是指在皮肤中检测到的所有病毒,是微生物群的重要组成部分。与细菌群相比,皮肤病毒群的发现要晚得多,最近的元基因组研究揭示了皮肤病毒群的存在。正常人的皮肤病毒组主要由噬菌体、乳头瘤病毒科(其基因组多样性已被证明非同寻常)和多瘤病毒科组成。病毒组中还有许多未知的病毒基因组等待鉴定。皮肤病毒群的组成已被证明是严格个性化的,而且随着时间的推移相对稳定,这是由于适应了每个人的遗传学、生活方式和进化过程中精挑细选的免疫耐受机制。然而,人们对皮肤病毒群及其与其他微生物群和宿主之间的所有相互作用研究甚少,这引起了人们越来越多的兴趣。事实上,人们已经观察到共生病毒群与皮肤之间的平衡状态发生了改变,从亚临床病毒性菌群失调到角质细胞或附属细胞的严重转变,不一而足。最近的这些观察结果正在激励人们寻找创新的解决方案,以测量甚至调节其病理表达,从而实现个性化医疗。
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[The cutaneous virome: from virology to personalized medicine].

The virome of the skin, defined as all viruses detected in the skin, represents a significant part of the microbiota. A much more recent discovery than the bacterial flora, the existence of the cutaneous virome has been revealed by recent metagenomic studies. The normal human skin virome is dominated by bacteriophages, Papillomaviridae, whose genomic diversity has proved extraordinary, and Polyomaviridae. Many yet unknown viral genomes within this virome await identification. The composition of the virome of the skin has been shown to be strictly individual and relatively stable over time, resulting from adaptation to everyone's genetics, lifestyle and mechanisms of immunological tolerance finely selected over the course of evolution. Yet little studied, the virome of the skin and all its interactions with other microbiota and the host are attracting growing interest. Indeed, constitutional or acquired alterations in the homeostasis between the commensal virome and the skin, ranging from sub-clinical viral dysbiosis to severe transformation of keratinocytes or adnexal cells, have been observed. These recent observations are stimulating the search for innovative solutions aimed at measuring or even modulating its pathological expression, with a view to personalized medicine.

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来源期刊
Virologie
Virologie VIROLOGY-
CiteScore
1.20
自引率
22.20%
发文量
31
审稿时长
>12 weeks
期刊介绍: Virologie offers top-level information for all those for whom virology is already the main or an important part of their activity: biologists, clinicians, pharmacists, veterinarians, agronomists, etc.
期刊最新文献
[37th International Conference on Antiviral Research (ICAR)]. [Joint Thesis Award 2023 of the Société française de virologie and ANRS | Maladies infectieuses émergentes]. [XIXe atelier international sur les parvovirus (Leuven, Belgique), 03-06 septembre 2024]. [From viral disease gender to viral species subclassification: how to find our way around?] [Human papillomaviruses : origin, oncogenic factors and markers for cervical cancer screening].
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