多细胞通讯的模式和主题。

Anna C Kögler, Patrick Müller
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引用次数: 0

摘要

信号通路具有多种相互作用的配体和受体变体,这些配体和受体变体被认为以组合方式发挥作用,引起不同的细胞反应。转录组分析表明,许多信号通路以组合的方式使用其成分,而令人惊讶的是,这些成分往往在不同的细胞状态之间共享。
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Modes and motifs in multicellular communication.

Signaling pathways feature multiple interacting ligand and receptor variants, which are thought to act in a combinatorial manner to elicit different cellular responses. Transcriptome analyses now suggest that many signaling pathways use their components in combinations that are surprisingly often shared between otherwise dissimilar cell states.

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