Mário Pinto, João Rodrigues, Marta Silva, Dionísio Maia, António Miguel
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引用次数: 0
摘要
一名 37 岁的男子因慢性腔隙性肺曲霉病和咯血而就诊，使用伏立康唑全身抗真菌治疗和支气管动脉栓塞治疗均无效。由于患者拒绝输血，手术切除不可行。随后，通过柔性支气管镜进行了十次两性霉素 B 腔内灌注。患者咯血停止，曲霉瘤消退，没有出现任何毒副作用。
Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis
A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma resolution were achieved, with no toxicity or side effects, and the clinical benefits were sustained at six months of follow-up.
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