{"title":"68Ga-Pentixafor PET 在原发性醛固酮增多症中的作用：系统回顾和荟萃分析","authors":"Min Wang, Jiayu Zhang, Bin Wu, Chunyin Zhang","doi":"10.1007/s40336-023-00610-3","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>The objective of this research is to conduct a thorough evaluation, both quantitatively and qualitatively, of the effectiveness of <sup>68</sup>Ga-Pentixafor PET within the Primary Aldosteronism framework.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We systematically searched the PubMed and Embase databases for relevant studies concerning the use of <sup>68</sup>Ga-Pentixafor PET in Primary Aldosteronism, spanning from the inception of these databases up to September 1, 2023. We assessed the quality of the chosen literature employing the QUADAS-2 diagnostic test evaluation tool. Following this, we conducted comprehensive analyses, both quantitatively and qualitatively, on relevant outcome measures extracted from the selected literature.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This study incorporated 7 articles encompassing a total of 474 patients. Among these articles, seven studies assessed the accuracy of <sup>68</sup>Ga-Pentixafor PET in distinguishing between different subtypes of Primary Aldosteronism, namely aldosterone-producing adenoma and non-aldosterone-producing adenoma. Of these, four studies presented complete 2 × 2 contingency tables for visual analysis, and three studies provided complete 2 × 2 contingency tables for semi-quantitative analysis. In addition, six studies reported the correlation between <sup>68</sup>Ga-Pentixafor PET findings and the clinical characteristics of patients. Furthermore, five studies explored the relationship between <sup>68</sup>Ga-Pentixafor PET outcomes and the clinical prognosis of patients. Five studies also investigated the correlation between <sup>68</sup>Ga-Pentixafor PET results and immunohistochemistry, whereas four studies assessed the link between <sup>68</sup>Ga-Pentixafor PET and nodule size.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p><sup>68</sup>Ga-Pentixafor PET displays substantial promise in enhancing the diagnosis of Primary Aldosteronism subtypes and precisely localizing aldosterone-producing adenoma. Furthermore, <sup>68</sup>Ga-Pentixafor PET imaging exhibits significant correlations with the clinical characteristics, clinical prognosis, immunohistochemistry, and nodule size in Primary Aldosteronism patients.</p>","PeriodicalId":48600,"journal":{"name":"Clinical and Translational Imaging","volume":"26 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of 68Ga-Pentixafor PET in Primary Aldosteronism: a systematic review and meta-analysis\",\"authors\":\"Min Wang, Jiayu Zhang, Bin Wu, Chunyin Zhang\",\"doi\":\"10.1007/s40336-023-00610-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>The objective of this research is to conduct a thorough evaluation, both quantitatively and qualitatively, of the effectiveness of <sup>68</sup>Ga-Pentixafor PET within the Primary Aldosteronism framework.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>We systematically searched the PubMed and Embase databases for relevant studies concerning the use of <sup>68</sup>Ga-Pentixafor PET in Primary Aldosteronism, spanning from the inception of these databases up to September 1, 2023. We assessed the quality of the chosen literature employing the QUADAS-2 diagnostic test evaluation tool. Following this, we conducted comprehensive analyses, both quantitatively and qualitatively, on relevant outcome measures extracted from the selected literature.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>This study incorporated 7 articles encompassing a total of 474 patients. Among these articles, seven studies assessed the accuracy of <sup>68</sup>Ga-Pentixafor PET in distinguishing between different subtypes of Primary Aldosteronism, namely aldosterone-producing adenoma and non-aldosterone-producing adenoma. Of these, four studies presented complete 2 × 2 contingency tables for visual analysis, and three studies provided complete 2 × 2 contingency tables for semi-quantitative analysis. In addition, six studies reported the correlation between <sup>68</sup>Ga-Pentixafor PET findings and the clinical characteristics of patients. Furthermore, five studies explored the relationship between <sup>68</sup>Ga-Pentixafor PET outcomes and the clinical prognosis of patients. Five studies also investigated the correlation between <sup>68</sup>Ga-Pentixafor PET results and immunohistochemistry, whereas four studies assessed the link between <sup>68</sup>Ga-Pentixafor PET and nodule size.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p><sup>68</sup>Ga-Pentixafor PET displays substantial promise in enhancing the diagnosis of Primary Aldosteronism subtypes and precisely localizing aldosterone-producing adenoma. Furthermore, <sup>68</sup>Ga-Pentixafor PET imaging exhibits significant correlations with the clinical characteristics, clinical prognosis, immunohistochemistry, and nodule size in Primary Aldosteronism patients.</p>\",\"PeriodicalId\":48600,\"journal\":{\"name\":\"Clinical and Translational Imaging\",\"volume\":\"26 1\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Translational Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s40336-023-00610-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Translational Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40336-023-00610-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
本研究旨在对68Ga-Pentixafor PET在原发性醛固酮增多症框架内的有效性进行全面的定量和定性评估。方法我们系统地检索了PubMed和Embase数据库中有关68Ga-Pentixafor PET在原发性醛固酮增多症中应用的相关研究，时间跨度从这些数据库建立之初到2023年9月1日。我们采用 QUADAS-2 诊断测试评估工具对所选文献进行了质量评估。随后，我们对从所选文献中提取的相关结果指标进行了全面的定量和定性分析。其中，7 项研究评估了 68Ga-Pentixafor PET 在区分原发性醛固酮增多症不同亚型（即醛固酮生成腺瘤和非醛固酮生成腺瘤）方面的准确性。其中，四项研究提供了完整的 2 × 2 或然率表进行直观分析，三项研究提供了完整的 2 × 2 或然率表进行半定量分析。此外，六项研究报告了 68Ga-Pentixafor PET 发现与患者临床特征之间的相关性。此外，五项研究探讨了 68Ga-Pentixafor PET 结果与患者临床预后之间的关系。五项研究还调查了 68Ga-Pentixafor PET 结果与免疫组化之间的相关性，而四项研究评估了 68Ga-Pentixafor PET 与结节大小之间的联系。此外，68Ga-Pentixafor PET 成像与原发性醛固酮增多症患者的临床特征、临床预后、免疫组化和结节大小有显著相关性。
The role of 68Ga-Pentixafor PET in Primary Aldosteronism: a systematic review and meta-analysis
Objective
The objective of this research is to conduct a thorough evaluation, both quantitatively and qualitatively, of the effectiveness of 68Ga-Pentixafor PET within the Primary Aldosteronism framework.
Methods
We systematically searched the PubMed and Embase databases for relevant studies concerning the use of 68Ga-Pentixafor PET in Primary Aldosteronism, spanning from the inception of these databases up to September 1, 2023. We assessed the quality of the chosen literature employing the QUADAS-2 diagnostic test evaluation tool. Following this, we conducted comprehensive analyses, both quantitatively and qualitatively, on relevant outcome measures extracted from the selected literature.
Results
This study incorporated 7 articles encompassing a total of 474 patients. Among these articles, seven studies assessed the accuracy of 68Ga-Pentixafor PET in distinguishing between different subtypes of Primary Aldosteronism, namely aldosterone-producing adenoma and non-aldosterone-producing adenoma. Of these, four studies presented complete 2 × 2 contingency tables for visual analysis, and three studies provided complete 2 × 2 contingency tables for semi-quantitative analysis. In addition, six studies reported the correlation between 68Ga-Pentixafor PET findings and the clinical characteristics of patients. Furthermore, five studies explored the relationship between 68Ga-Pentixafor PET outcomes and the clinical prognosis of patients. Five studies also investigated the correlation between 68Ga-Pentixafor PET results and immunohistochemistry, whereas four studies assessed the link between 68Ga-Pentixafor PET and nodule size.
Conclusion
68Ga-Pentixafor PET displays substantial promise in enhancing the diagnosis of Primary Aldosteronism subtypes and precisely localizing aldosterone-producing adenoma. Furthermore, 68Ga-Pentixafor PET imaging exhibits significant correlations with the clinical characteristics, clinical prognosis, immunohistochemistry, and nodule size in Primary Aldosteronism patients.
期刊介绍：
Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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