作为一种公共卫生威胁出现的异丙嗪:麻醉医师在围手术期护理方面需要了解什么?

IF 5.1 2区 医学 Q1 ANESTHESIOLOGY Regional Anesthesia and Pain Medicine Pub Date : 2025-01-07 DOI:10.1136/rapm-2023-105190
Pawan K Solanki, Samir Yellapragada, Brendan Lynch, Maria Eibel, Eugene R Viscusi, Trent Emerick
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摘要

本文探讨了在美国迅速出现的对甲苯噻嗪的接触及其对麻醉医师的影响。异丙嗪是一种常用于兽医的非阿片类镇静和镇痛药,越来越多地被发现在非法药物供应中掺杂,导致严重的健康问题。本文将讨论异丙嗪的药理特性、临床效果及其对临床医师带来的挑战。本文还提供了麻醉医师处理这些潜在病例的围术期策略。此外,本文还认为有必要从流行病学的角度来认识这种新出现的公共卫生威胁,以便进行检测和多学科合作。手稿最后强调了麻醉医师在管理恶嗪的临床影响和促进旨在遏制恶嗪滥用的公共卫生策略方面所扮演的角色。
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Emergence of xylazine as a public health threat: what does the anesthesiologist need to know for perioperative care?

This paper explores the rapid emergence of xylazine exposure in the USA and its implications for anesthesiologists. Xylazine, a non-opioid sedative and analgesic often used in veterinary medicine, has increasingly been found as an adulterant in the illicit substance supply, leading to serious health implications. The pharmacological properties of xylazine, its clinical effects, and the challenges it poses for clinicans will be discussed. Perioperative strategies for anesthesiologists to manage these potential cases are provided. Furthermore, this paper necessitates an epidemiological understanding for detection and multidisciplinary collaboration in addressing this emerging public health threat. The manuscript concludes by emphasizing the role anesthesiologists will have to play in managing the clinical implications of xylazine and contributing to public health strategies aimed at curbing its misuse.

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来源期刊
CiteScore
8.50
自引率
11.80%
发文量
175
审稿时长
6-12 weeks
期刊介绍: Regional Anesthesia & Pain Medicine, the official publication of the American Society of Regional Anesthesia and Pain Medicine (ASRA), is a monthly journal that publishes peer-reviewed scientific and clinical studies to advance the understanding and clinical application of regional techniques for surgical anesthesia and postoperative analgesia. Coverage includes intraoperative regional techniques, perioperative pain, chronic pain, obstetric anesthesia, pediatric anesthesia, outcome studies, and complications. Published for over thirty years, this respected journal also serves as the official publication of the European Society of Regional Anaesthesia and Pain Therapy (ESRA), the Asian and Oceanic Society of Regional Anesthesia (AOSRA), the Latin American Society of Regional Anesthesia (LASRA), the African Society for Regional Anesthesia (AFSRA), and the Academy of Regional Anaesthesia of India (AORA).
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