Kaida Kuang, Ya Li, Yang Chen, Yu Ji and Nengqin Jia
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引用次数: 0
摘要
传统的单信号或新兴的夹层型双信号电化学发光(ECL)免疫传感器/自适应传感器可精确检测小分子,但存在设置复杂、处理时间长和不可重复使用等问题。在这里,我们展示了一种基于 Mn2SnO4 纳米立方体的简化分子印迹 ECL 传感器。作为一种 n 型半导体,Mn2SnO4 具有许多活性位点,可以捕获电子加速化学反应,从而增强 ECL 活性和稳定性。我们首次验证了 Mn2SnO4 发光体在 K2S2O8 核心反应物存在下的强阴极 ECL 发射。所提出的 ECL 传感器适用于利巴韦林(RBV)的灵敏检测,具有宽线性范围(1-2000 ng mL-1)、低检测限(0.85 ng mL-1,S/N = 3)、高稳定性、特异性和重现性,以及在真实牛奶和鸡肉样品中的检测能力。这项工作突出了单半导体发光体驱动的分子印迹 ECL 传感器,满足了食品安全检测中简单而高性能传感的最初愿望。
A simplified molecularly imprinted ECL sensor based on Mn2SnO4 nanocubes for sensitive detection of ribavirin†
Conventional single-signal or emerging sandwich-type double-signal electrochemiluminescence (ECL) immunosensors/aptasensors have offered accurate detection of small molecules, yet suffer from complicated setup, long processing time, and non-reusability. Here, we demonstrate a simplified molecularly imprinted ECL sensor based on Mn2SnO4 nanocubes. As an n-type semiconductor, Mn2SnO4 has numerous active sites that can capture electrons to accelerate chemical reactions, resulting in enhanced ECL activity and stability. For the first time, we verify a robust cathodic ECL emission of Mn2SnO4 luminophores in the presence of K2S2O8 coreactants. The proposed ECL sensor applies to the sensitive detection of ribavirin (RBV), endowing a wide linear range (1–2000 ng mL−1), low detection limit (0.85 ng mL−1, S/N = 3), high stability, specificity, and reproducibility, and the detection capability in real milk and chicken samples. This work highlights single semiconductor luminophore-driven molecularly imprinted ECL sensors, meeting the original aspiration of uncomplicated but high-performance sensing in food safety inspection.