TLR10：一个有趣的 Toll 样受体，有许多未解之谜。

IF 4.7 3区医学 Q2 IMMUNOLOGY Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-01-19 DOI:10.1159/000535523

Carolina Rego Rodrigues, Yadu Balachandran, Gurpreet Kaur Aulakh, Baljit Singh

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引用次数: 0

摘要

背景：Toll 样受体（TLRs）是先天性免疫系统中最早发现的模式识别受体（PRRs）之一。TLR 家族在小鼠中有 12 个成员（TLR1-TLR9、TLR11-TLR13），在人类中有 10 个成员（TLR1-TLR10），其中 TLR10 是最新发现的成员。摘要：关于 TLR 的研究相当多，但 TLR10 被称为 "孤儿受体"，因为缺乏有关其信号、作用和配体的信息。尽管最近有研究指出了潜在的 TLR10 配体，但其功能和信号通路仍有待确定：本综述深入探讨了有关 TLR10 促炎和抗炎特性的最新研究成果，旨在概述现有成果并指出有关该受体的未来研究课题。

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TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions.

Background: Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1-TLR9, TLR11-TLR13) in mice and 10 members (TLR1-TLR10) in humans, with TLR10 being the latest identified.

Summary: Considerable research has been performed on TLRs; however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing towards the potential TLR10 ligands, their function and signalling pathway are yet to be determined.

Key messages: This review gives an insight into recent findings on TLR10's pro- and anti-inflammatory properties, with the goal of outlining existing results and indicating future research topics on this receptor.

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来源期刊

Journal of Innate Immunity 医学-免疫学

CiteScore

10.50

自引率

1.90%

发文量

审稿时长

7.5 months

期刊介绍： The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.