肥胖和 2 型糖尿病患者体内白细胞介素-6、胰岛素和胰高血糖素的浓度与 IL6 和 INS 基因的单核苷酸多态性。

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2024-01-12 eCollection Date: 2024-01-01 DOI:10.1155/2024/7529779
Magdalena Król-Kulikowska, Iwona Urbanowicz, Marta Kepinska
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引用次数: 0

摘要

肥胖症和糖尿病是现代医学的一个难题。尽管导致这些疾病发生的环境因素已广为人知,但对遗传因素的研究仍在继续。与此同时,炎症在肥胖症和糖尿病病理生理学中的作用也日益受到重视。因此,本研究旨在调查两个选定的多态性(rs1800795 和 rs3842729)对肥胖和 2 型糖尿病发病的影响。本研究共调查了 118 名参与者,包括对照组(非肥胖组和非糖尿病组)、肥胖组和糖尿病组。基因型分析采用 PCR-RFLP 方法进行。研究表明,与 G/C 和 C/C 基因型患者相比,rs1800795 多态性(IL6)G/G 基因型患者罹患 2 型糖尿病的几率要低数倍。然而,rs3842729 多态性(INS)并不直接影响肥胖或 2 型糖尿病(T2D)的风险,尽管在肥胖和糖尿病患者中观察到胰岛素浓度升高。这些结果证实了 rs1800795 多态性对糖尿病发病的影响;然而,这种关系更为复杂,需要进一步研究其他因素。
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The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes.

Obesity and diabetes are a problem of modern medicine. Although the environmental factors contributing to the development of these diseases are widely known, research into genetic factors is still ongoing. At the same time, the role of inflammation in the pathophysiology of obesity and diabetes is increasingly emphasized. Therefore, the purpose of this study was to investigate the influence of two selected polymorphisms (rs1800795 and rs3842729) on the development of obesity and type 2 diabetes. In this study, 118 participants were examined, including a control group (nonobese and nondiabetic group), an obese group, and a diabetic group. Genotype analysis was performed using the PCR-RFLP method. It has been shown that in patients with the G/G genotype within the rs1800795 polymorphism (IL6), the chance of developing type 2 diabetes is several times lower compared to patients with the G/C and C/C genotypes. However, the rs3842729 polymorphism (INS) does not directly affect the risk of obesity or type 2 diabetes (T2D), although elevated insulin concentrations have been observed in obese and diabetic patients. These results confirm the impact of the rs1800795 polymorphism on the development of diabetes; however, this relationship is more complex and requires further research on other factors.

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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
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