Eleanor K Wyatt, Verena Affolter, Stefano Borio, Alexandra Guillen, Sara Verganti, Sue Murphy, Damiano Ballarini, Frane Banovic, Vanessa Schmidt, Jean-Benoit Tanis
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This retrospective study describes clinicopathological findings, treatment and outcome of 11 dogs with suspected MIS. Dogs with multiple mast cell tumours were excluded. Histopathology reports (n = 5) or slides (n = 6) were reviewed. KIT mutation analysis including exons 8, 9, 11, 14 and 17 were analysed in eight dogs. Median age at diagnosis was 4 years (range, 1-12). Typical clinical signs included multifocal to generalised nodules and papules. Histologically, skin lesions were characterised by dermal infiltration of well-differentiated mast cells. KIT mutations were detected in 3/8 dogs (exon 9: n = 2; exon 11: n = 1). One dog had mastocytaemia suggesting possible SM. Glucocorticoids were mostly successful with lesion improvement in all treated dogs (n = 8). This cohort highlights resemblances between human and canine MIS. Further studies are required to confirm these findings and establish diagnostic criteria for CM and MIS associated with SM in dogs.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":"136-148"},"PeriodicalIF":2.3000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mastocytosis in the skin in dogs: A multicentric case series.\",\"authors\":\"Eleanor K Wyatt, Verena Affolter, Stefano Borio, Alexandra Guillen, Sara Verganti, Sue Murphy, Damiano Ballarini, Frane Banovic, Vanessa Schmidt, Jean-Benoit Tanis\",\"doi\":\"10.1111/vco.12962\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Canine cutaneous mastocytosis (CM) is rare in contrast to canine mast cell tumours. In humans, CM commonly affects children and is usually indolent with possible spontaneous resolution. 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Histologically, skin lesions were characterised by dermal infiltration of well-differentiated mast cells. KIT mutations were detected in 3/8 dogs (exon 9: n = 2; exon 11: n = 1). One dog had mastocytaemia suggesting possible SM. Glucocorticoids were mostly successful with lesion improvement in all treated dogs (n = 8). This cohort highlights resemblances between human and canine MIS. 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引用次数: 0
摘要
犬皮肤肥大细胞增多症(CM)与犬肥大细胞瘤相比非常罕见。犬皮肤肥大细胞增多症(CM)与犬肥大细胞瘤相比较为罕见。在人类中,犬皮肤肥大细胞增多症常见于儿童,通常症状不明显,可自行缓解。骨髓受累的全身性肥大细胞增生症(SM)通常会影响成年人,预后较差,而且通常会出现皮肤病变。皮肤肥大细胞增多症"(Mastocytosis in the skin,MIS)是皮肤病变的首选术语,如果无法进行骨髓评估的话,狗的情况往往如此。在人类 SM 和 CM 中,通常会检测到 KIT 突变。兽医文献表明,人类和犬类 MIS 的临床表现相似,但数据有限,而且很少对 KIT 基因突变进行评估。这项回顾性研究描述了 11 只疑似肥大细胞瘤犬的临床病理结果、治疗和预后。排除了患有多发性肥大细胞瘤的犬只。对组织病理学报告(5 例)或切片(6 例)进行了审查。对 8 只狗进行了 KIT 突变分析,包括第 8、9、11、14 和 17 号外显子。确诊时的中位年龄为 4 岁(1-12 岁)。典型的临床症状包括多灶性至全身性结节和丘疹。组织学上,皮肤病变的特征是真皮浸润分化良好的肥大细胞。3/8只狗检测到KIT突变(外显子9:n = 2;外显子11:n = 1)。一只狗患有肥大细胞血症,提示可能患有 SM。糖皮质激素在所有接受治疗的狗(n = 8)中都取得了成功,病变得到了改善。该队列突出了人类和犬类 MIS 之间的相似性。需要进一步的研究来证实这些发现,并建立与犬 SM 相关的 CM 和 MIS 的诊断标准。
Mastocytosis in the skin in dogs: A multicentric case series.
Canine cutaneous mastocytosis (CM) is rare in contrast to canine mast cell tumours. In humans, CM commonly affects children and is usually indolent with possible spontaneous resolution. Systemic mastocytosis (SM) with bone marrow involvement typically affects adults, can have a poor outcome, and often includes skin lesions. 'Mastocytosis in the skin' (MIS) is the preferred term of skin lesions, if bone marrow evaluations are not available, which is often the cases in dogs. In human SM and CM, KIT mutations are often detected. The veterinary literature suggests clinical resemblances between human and canine MIS, but data is limited, and KIT mutations are rarely assessed. This retrospective study describes clinicopathological findings, treatment and outcome of 11 dogs with suspected MIS. Dogs with multiple mast cell tumours were excluded. Histopathology reports (n = 5) or slides (n = 6) were reviewed. KIT mutation analysis including exons 8, 9, 11, 14 and 17 were analysed in eight dogs. Median age at diagnosis was 4 years (range, 1-12). Typical clinical signs included multifocal to generalised nodules and papules. Histologically, skin lesions were characterised by dermal infiltration of well-differentiated mast cells. KIT mutations were detected in 3/8 dogs (exon 9: n = 2; exon 11: n = 1). One dog had mastocytaemia suggesting possible SM. Glucocorticoids were mostly successful with lesion improvement in all treated dogs (n = 8). This cohort highlights resemblances between human and canine MIS. Further studies are required to confirm these findings and establish diagnostic criteria for CM and MIS associated with SM in dogs.
期刊介绍:
Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.