棘皮果中可溶性黑色素的抗生物膜、细胞抗氧化、抗炎、免疫调节、细胞毒性和抗突变活性

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Advances in Traditional Medicine Pub Date : 2024-01-11 DOI:10.1007/s13596-023-00735-w
Yesmi P. Ahumada-Santos, Gabriela López-Angulo, Rebeca M. Pinto-González, Aldo F. Clemente-Soto, José A. López-Valenzuela, Francisco Delgado-Vargas
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引用次数: 0

摘要

黑色素是一种广泛分布的生物聚合物,具有重要的生物活性。然而,对水果黑色素的研究却很少。这项研究评估了从棘皮果(Randia echinocarpa)果实中分离出来的可溶性黑色素(SMs)的抗生物膜、细胞抗氧化、抗炎、免疫调节、细胞毒性和抗突变活性。当浓度为 1000 微克/毫升时,可溶性黑色素对金黄色葡萄球菌 MDR 和 ATCC 43300 的生物膜形成有 60% 的抑制作用;当浓度为 50 微克/毫升时,可溶性黑色素具有细胞抗氧化活性(60.02%);通过提高外周血单核细胞(PBMC)增殖指数(50 微克/毫升时为 1.09),可溶性黑色素具有免疫调节作用;对 HeLa 细胞增殖的抑制率为 77.39% (IC50 = 9.34 微克/毫升)。木瓜蛋白酶对伤寒沙门氏菌 YG1024 株既无毒性也无诱变性,对 1-硝基苯芘诱变性的抑制率为 30.2%。木瓜蛋白酶的生物活性支持其在营养保健品和药物配方中的应用潜力。
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Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit

Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% (IC50 = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations.

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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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