用于 1 型糖尿病的闭环控制人工胰腺:设计、实施和评估

Mohamed Ahmed Massoud, Wael Abouelwafa Ahmed, Bassma H. Elwakil, Mohamed I. Badawi
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摘要

胰岛素供应闭环控制装置通常被称为人工胰腺,用于治疗 1 型糖尿病。本研究介绍了闭环控制系统的现状和预期的未来发展,同时讨论了使用模糊模型预测控制器进行自动血糖管理的困难。通过限制或预防短期和长期影响,这些解决方案减轻了糖尿病患者的日常管理压力。本文调查了当前有关人工胰腺的文献,并提出了加强其调节的策略。相反,闭环系统可以提供适当剂量和时间的胰岛素和葡萄糖。人工胰腺的算法需要使用葡萄糖传感器监测患者的血糖水平,然后向胰岛素泵发送信号,根据患者所需的胰岛素水平改变基础胰岛素剂量。无创葡萄糖传感器原型的研究结果表明,近红外技术在生物医学领域,特别是用于连续、实时葡萄糖监测的光学光谱学领域前景广阔。无创葡萄糖传感器原型的结果表明,近红外技术在生物医学中的应用前景广阔,尤其是在用于连续、实时葡萄糖监测的光学光谱学方面。
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ARTIFICIAL PANCREAS WITH CLOSED-LOOP CONTROL FOR TYPE 1 DIABETES: DESIGN, IMPLEMENTATION, AND EVALUATION
A closed-loop controller of insulin supply, often known as an artificial pancreas, is used to treat type 1 diabetes. This research presents the status of closed-loop control systems and anticipated future developments while discussing the difficulties of automated glucose management using fuzzy model predictive Controller. By limiting or preventing short-and long-term impacts, these solutions lessen the daily strain of managing diabetes. This paper investigates the current literature on artificial pancreas and suggests a strategy to enhance its regulation. Contrarily, a closed loop system can deliver the proper dose and timing of insulin and glucose. The artificial pancreas' algorithm entails monitoring a patient's blood glucose levels using a glucose sensor before sending a signal to an insulin pump to alter basal insulin dosage in accordance with the desired level of insulin the patient requires. The noninvasive glucose sensor prototype's results point to a promising future for NIR technology in biomedicine, particularly in optical spectroscopy for continuous, real-time glucose monitoring. The outcomes of the non-invasive glucose sensor prototype show that NIR technology has promising applications in biomedicine, particularly in optical spectroscopy for continuous, real-time glucose monitoring.
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