替米沙坦脂质体:抗击乳腺癌的创新武器

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摘要

本研究的重点是开发一种脂质体制剂,用于在乳腺癌治疗中靶向输送替米沙坦。替米沙坦是一种具有潜在抗癌特性的药物,已被包裹在脂质体中,脂质体是一种以脂质为基础的囊泡,因其具有增强药物输送和改善治疗效果的能力而闻名。研究人员对载入替米沙坦的脂质体进行了配制和表征,评估了其大小、形状和药物释放情况等因素。研究结果表明,脂质体制剂能有效包裹替米沙坦,保持其药理特性。开发这种脂质体制剂有望促进乳腺癌疗法的发展,为提高疗效和减少副作用提供了可能。这项研究有助于在乳腺癌治疗领域不断探索创新的给药策略。乳腺癌是一种影响全球妇女的普遍而具有挑战性的恶性肿瘤。为了寻求更有效、更有针对性的治疗方法,开发脂质体制剂以向乳腺癌细胞输送治疗药物已成为一条前景广阔的途径。替米沙坦(Telmisartan)最初被认为具有抗高血压的特性,但其潜在的抗癌作用也受到越来越多的研究。本研究深入探讨了替米沙坦脂质体制剂的设计和评估,旨在提高其对乳腺癌的治疗潜力。制剂过程包括将替米沙坦封装在脂质体中,脂质体因其能够携带多种药物、保护药物不被降解以及增强对肿瘤细胞的选择性递送而闻名。
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Telmisartan-loaded liposomes: An innovative weapon against breast cancer

This study focuses on the development of a liposomal preparation for the targeted delivery of Telmisartan in the context of breast cancer treatment. Telmisartan, a pharmaceutical agent with potential anticancer properties, has been encapsulated within liposomes, lipid-based vesicles known for their capacity to enhance drug delivery and improve therapeutic outcomes. The formulation and characterization of Telmisartan-loaded liposomes were conducted, evaluating factors such as size, shape, and drug release profiles. The findings demonstrate that the liposomal preparation effectively encapsulates Telmisartan, maintaining its pharmacological properties. The development of such liposomal formulations holds promise for advancing breast cancer therapies, offering the potential for enhanced treatment efficacy and reduced side effects. This research contributes to the ongoing efforts to explore innovative drug delivery strategies in the realm of breast cancer treatment. Breast cancer is a pervasive and challenging malignancy affecting women worldwide. In the quest for more effective and targeted treatment approaches, the development of liposomal preparations for delivering therapeutic agents to breast cancer cells has emerged as a promising avenue. Telmisartan, originally recognized for its antihypertensive properties, has been increasingly investigated for its potential anticancer effects. This study delves into the design and evaluation of a liposomal formulation for Telmisartan, aiming to enhance its therapeutic potential in breast cancer. The formulation process involved the encapsulation of Telmisartan within lipid-based liposomes, which are well-known for their ability to carry a variety of drugs, protect them from degradation, and enhance their selective delivery to tumor cells.

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