复发性着床失败患者中使用 CD138 诊断出的慢性子宫内膜炎的发病率和混杂因素。

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-06-01 Epub Date: 2024-01-24 DOI:10.5653/cerm.2023.06170
Hye Jeong Hue, Hyunji Choi, Hyun Kyoung Lee, Jung Ryeol Lee, Byung Chul Jee, Chang Woo Choo, Seul Ki Kim
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引用次数: 0

摘要

研究目的这项回顾性研究旨在调查不孕妇女中使用 CD138 免疫组化诊断的慢性子宫内膜炎的患病率,并评估慢性子宫内膜炎与复发性着床失败(RIF)之间的关联:共有 266 名在 2019 年至 2020 年期间因不孕而接受宫腔镜检查的患者被纳入分析。其中,136 名 RIF 患者和 130 名非 RIF 患者被纳入研究。研究人员获得了 CD138 免疫组化检测结果、血液生物标志物(包括自然杀伤细胞、白细胞和淋巴细胞与中性粒细胞比率)以及妊娠结局数据。如果 CD138 检测结果呈阳性,患者将接受抗生素治疗:CD138阳性患者的总比例为32.7%(87/266)。CD138 阳性率与植入失败的周期数无关。在 RIF 患者组中,CD138 阳性与外周血标志物之间没有发现明显的关联。结论:使用抗生素治疗慢性子宫内膜炎的不孕妇女与无慢性子宫内膜炎的不孕妇女的临床妊娠率相似:结论:为提高不孕症患者的妊娠率,将 CD138 检测与其他实验室检测结合起来并在检测结果呈阳性时进行抗生素治疗可能会有所帮助。
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Prevalence and confounders of chronic endometritis diagnosed using CD138 in patients with recurrent implantation failure.

Objective: This retrospective study aimed to investigate the prevalence of chronic endometritis, diagnosed using CD138 immunohistochemistry, among infertile women and to assess the association between chronic endometritis and recurrent implantation failure (RIF).

Methods: In total, 266 patients who underwent hysteroscopy due to infertility between 2019 and 2020 were included in the analysis. Of these, 136 patients with RIF and 130 non-RIF patients were included in the study. CD138 immunohistochemistry test results, blood biomarkers (including natural killer cells, white blood cells, and the lymphocyte-to-neutrophil ratio), and data on pregnancy outcomes were obtained. If the CD138 test yielded a positive result, the patients received antibiotic treatment.

Results: The overall proportion of CD138-positive patients was 32.7% (87/266). The CD138 positivity rate was not related to the number of cycles with implantation failure. In the RIF patient group, no significant associations were found between CD138 positivity and peripheral blood markers. The clinical pregnancy rates were similar between infertile women treated with antibiotics for chronic endometritis and those without chronic endometritis.

Conclusion: To improve the pregnancy rate in infertile patients, it may be helpful to combine CD138 testing with other laboratory tests and administer antibiotic treatment if the result is positive.

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