外阴癌前病变:综述文章。

IF 2 Q2 OBSTETRICS & GYNECOLOGY Obstetrics and Gynecology Science Pub Date : 2024-03-01 Epub Date: 2024-01-23 DOI:10.5468/ogs.23274
Sumedha Gupta, Sana Ahuja, Dheer Singh Kalwaniya, Saritha Shamsunder, Shalu Solanki
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引用次数: 0

摘要

外阴上皮内瘤变(VIN)是一种非侵入性鳞状病变,是外阴鳞状细胞癌的前兆。目前还没有检测 VIN 的筛查试验,需要进行活组织检查来确诊。尽管外阴鳞状细胞癌与宫颈上皮内瘤变有许多共同的风险因素,但其诊断仍面临挑战,这也是其发病率不断上升的原因之一。本研究旨在分析导致 VIN 发生的潜在风险因素,识别特定高危人群,并确定适当的治疗方法。分化型 VIN(dVIN)和普通型 VIN(uVIN)是 VIN 的分类。分化型外阴阴道炎(dVIN)与其他外阴炎症性疾病(如苔藓硬化症)有关,而更常见的普通型外阴阴道炎(uVIN)则与潜在的人类乳头瘤病毒感染有关。分化型 VIN 患者罹患侵袭性恶性肿瘤的风险更高。外阴上皮内瘤变是外阴的一种浸润性肿瘤,目前几乎没有有效的监测或管理技术。对于可疑病变,必须进行彻底检查和重点活检。根据每位患者的具体需求,可采用手术和药物治疗相结合的方法。
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Vulval premalignant lesions: a review article.

Vulvar intraepithelial neoplasia (VIN) is a noninvasive squamous lesion that is a precursor of vulvar squamous cell cancer. Currently, no screening tests are available for detecting VIN, and a biopsy is performed to confirm the clinical diagnosis. Despite sharing many risk factors with cervical intraepithelial neoplasia, the diagnosis of VIN is poses challenges, contributing to its increasing prevalence. This study aimed to analyze the underlying risk factors that contribute to the development of VIN, identify specific populations at risk, and define appropriate treatment approaches. Differentiated VIN (dVIN) and usual VIN (uVIN) are the classifications of VIN. While dVIN is associated with other vulvar inflammatory disorders, such as lichen sclerosis, the more prevalent uVIN is associated with an underlying human papillomavirus infection. Patients with differentiated VIN have an increased risk of developing invasive malignancies. Few effective surveillance or management techniques exist for vulvar intraepithelial neoplasia, a preinvasive neoplasm of the vulva. For suspicious lesions, a thorough examination and focused biopsy are necessary. Depending on the specific needs of each patient, a combination of surgical and medical approaches can be used.

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来源期刊
Obstetrics and Gynecology Science
Obstetrics and Gynecology Science Medicine-Obstetrics and Gynecology
CiteScore
3.80
自引率
15.80%
发文量
58
审稿时长
16 weeks
期刊介绍: Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.
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