洞察前列腺癌干细胞的生物学特性:前列腺癌干细胞的生物学特性:对癌症进展和治疗的影响

Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost
{"title":"洞察前列腺癌干细胞的生物学特性:前列腺癌干细胞的生物学特性:对癌症进展和治疗的影响","authors":"Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost","doi":"10.2174/011574888X268997231206112056","DOIUrl":null,"url":null,"abstract":"<p><p>Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted\nthe critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis\nof the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal\nand differentiation capabilities, making them a potential therapeutic target for effective PCa\ntreatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research\nhas shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3,\nAKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally,\nnon-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators\nof PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could\noffer new opportunities for the management of PCa. This review summarizes the current knowledge\nsurrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.</p>","PeriodicalId":93971,"journal":{"name":"Current stem cell research & therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy\",\"authors\":\"Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost\",\"doi\":\"10.2174/011574888X268997231206112056\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted\\nthe critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis\\nof the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal\\nand differentiation capabilities, making them a potential therapeutic target for effective PCa\\ntreatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research\\nhas shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3,\\nAKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally,\\nnon-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators\\nof PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could\\noffer new opportunities for the management of PCa. This review summarizes the current knowledge\\nsurrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.</p>\",\"PeriodicalId\":93971,\"journal\":{\"name\":\"Current stem cell research & therapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current stem cell research & therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/011574888X268997231206112056\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current stem cell research & therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/011574888X268997231206112056","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

前列腺癌(PCa)是男性第二大高发癌症。最近的研究强调了前列腺癌干细胞(PCSCs)在前列腺组织肿瘤发生和转移中的关键作用。PCSCs 是前列腺中一种罕见的细胞群,具有自我更新和分化能力,是有效治疗 PCa 的潜在治疗靶点。因此,靶向 PCSCs 可能是治疗 PC 病的一种新策略。研究表明,Notch、SHH、TGF-β、Wnt、STAT3、AKT 和表皮生长因子受体(EGFR)等多种信号通路参与调控 PCSC 的增殖、迁移和侵袭。此外,长 ncRNA 和 miRNA 等非编码 RNA 已成为 PCSC 发病机制和耐药性的关键调控因子。在此,我们强调靶向这些通路可为治疗 PCa 提供新的机会。本综述总结了目前围绕与 PCSC 肿瘤发生和侵袭性有关的重要信号通路的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy

Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted the critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis of the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal and differentiation capabilities, making them a potential therapeutic target for effective PCa treatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research has shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3, AKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally, non-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators of PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could offer new opportunities for the management of PCa. This review summarizes the current knowledge surrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Effect of miR-98/IL-6/STAT3 on Autophagy and Apoptosis of Cardiac Stem Cells Under Hypoxic Conditions In vitro. Human Umbilical Cord Mesenchymal Stem Cell-derived Exosome Regulates Intestinal Type 2 Immunity. Kartogenin Induces Chondrogenesis in Cartilage Progenitor Cells and Attenuates Cell Hypertrophy in Marrow-Derived Stromal Cells. The Mechanisms of Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Encephalomyelitis. The Role of Stem Cell Therapies in the Treatment of Neurodegenerative Diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1