{"title":"洞察前列腺癌干细胞的生物学特性:前列腺癌干细胞的生物学特性:对癌症进展和治疗的影响","authors":"Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost","doi":"10.2174/011574888X268997231206112056","DOIUrl":null,"url":null,"abstract":"<p><p>Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted\nthe critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis\nof the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal\nand differentiation capabilities, making them a potential therapeutic target for effective PCa\ntreatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research\nhas shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3,\nAKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally,\nnon-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators\nof PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could\noffer new opportunities for the management of PCa. This review summarizes the current knowledge\nsurrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.</p>","PeriodicalId":93971,"journal":{"name":"Current stem cell research & therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy\",\"authors\":\"Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost\",\"doi\":\"10.2174/011574888X268997231206112056\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted\\nthe critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis\\nof the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal\\nand differentiation capabilities, making them a potential therapeutic target for effective PCa\\ntreatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research\\nhas shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3,\\nAKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally,\\nnon-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators\\nof PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could\\noffer new opportunities for the management of PCa. This review summarizes the current knowledge\\nsurrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.</p>\",\"PeriodicalId\":93971,\"journal\":{\"name\":\"Current stem cell research & therapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current stem cell research & therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/011574888X268997231206112056\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current stem cell research & therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/011574888X268997231206112056","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy
Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted
the critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis
of the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal
and differentiation capabilities, making them a potential therapeutic target for effective PCa
treatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research
has shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3,
AKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally,
non-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators
of PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could
offer new opportunities for the management of PCa. This review summarizes the current knowledge
surrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.