洞察前列腺癌干细胞的生物学特性:前列腺癌干细胞的生物学特性:对癌症进展和治疗的影响

Jafar Poodineh, Azimeh Akhlaghpour, Farhoodeh Ghaedrahmati, Fatemeh Khojasteh Pour, Shahab Uddin, Maryam Farzaneh, Shirin Azizidoost
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引用次数: 0

摘要

前列腺癌(PCa)是男性第二大高发癌症。最近的研究强调了前列腺癌干细胞(PCSCs)在前列腺组织肿瘤发生和转移中的关键作用。PCSCs 是前列腺中一种罕见的细胞群,具有自我更新和分化能力,是有效治疗 PCa 的潜在治疗靶点。因此,靶向 PCSCs 可能是治疗 PC 病的一种新策略。研究表明,Notch、SHH、TGF-β、Wnt、STAT3、AKT 和表皮生长因子受体(EGFR)等多种信号通路参与调控 PCSC 的增殖、迁移和侵袭。此外,长 ncRNA 和 miRNA 等非编码 RNA 已成为 PCSC 发病机制和耐药性的关键调控因子。在此,我们强调靶向这些通路可为治疗 PCa 提供新的机会。本综述总结了目前围绕与 PCSC 肿瘤发生和侵袭性有关的重要信号通路的知识。
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Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy

Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted the critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis of the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal and differentiation capabilities, making them a potential therapeutic target for effective PCa treatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research has shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3, AKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally, non-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators of PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could offer new opportunities for the management of PCa. This review summarizes the current knowledge surrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.

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