针对疾病靶向治疗的多特异性抗体的机制驱动设计。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED Annual review of chemical and biomolecular engineering Pub Date : 2024-01-26 DOI:10.1146/annurev-chembioeng-100522-102155
Justyn Fine, Bunyarit Meksiriporn, Jiacheng Tan, Jamie B Spangler
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引用次数: 0

摘要

以抗体为基础的疗法是一类发展迅速的药物化合物。然而,单克隆抗体只能特异性地作用于一个靶点,往往缺乏治疗复杂疾病的复杂机理。为了扩大抗体疗法的用途,人们在设计多特异性抗体方面投入了大量精力,这种抗体使用单个分子作用于多个靶点。这些努力最终取得了显著的转化进展,包括九种获得美国食品药品管理局批准的多特异性抗体,以及无数处于不同临床前或临床开发阶段的其他抗体。在这篇综述中,我们将讨论几类已获得临床批准或在早期开发阶段显示出前景的多特异性抗体。我们的重点是多特异性抗体的分子机制,以及这些机制如何为其定制设计和配方提供依据。我们特别讨论了针对多种疾病标志物的多特异性抗体、多异位抗体和免疫干扰抗体。总之,这些创新的多特异性抗体设计正在推动整个免疫治疗领域取得令人振奋的进展。化学与生物分子工程年度综述》第 15 卷的最终在线出版日期预计为 2024 年 6 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
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Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment.

Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic intricacy to treat complex diseases. To expand the utility of antibody therapies, significant efforts have been invested in designing multispecific antibodies, which engage multiple targets using a single molecule. These efforts have culminated in remarkable translational progress, including nine US Food and Drug Administration-approved multispecific antibodies, with countless others in various stages of preclinical or clinical development. In this review, we discuss several categories of multispecific antibodies that have achieved clinical approval or shown promise in earlier stages of development. We focus on the molecular mechanisms used by multispecific antibodies and how these mechanisms inform their customized design and formulation. In particular, we discuss multispecific antibodies that target multiple disease markers, multiparatopic antibodies, and immune-interfacing antibodies. Overall, these innovative multispecific antibody designs are fueling exciting advances across the immunotherapeutic landscape. Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering , Volume 15 is June 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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