急性面部神经痛与开始使用恩曲他滨/替诺福韦进行艾滋病毒预防性治疗有关：一项预防性治疗示范试验中两例病例的报告。

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES Sexual health Pub Date : 2024-01-01 DOI:10.1071/SH23129

Zhuoheng Yin, Rayner Kay Jin Tan, Joseph D Tucker, Quanmin Li, Renslow Sherer, Linghua Li, Weiming Tang

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引用次数: 0

摘要

背景：恩曲他滨（FTC）和富马酸替诺福韦二吡呋酯（TDF）固定剂量复方制剂（FTC/TDF）一般耐受性良好，但也有治疗相关不良事件的报道：我们报告了两例在中国PrEP示范试验中使用FTC/TDF PrEP并出现急性神经痛的病例：结果：神经症状在停止治疗后缓解。据报道，这些症状与其中一例患者之前使用多罗替拉韦（DTG）+FTC+替诺福韦-阿拉非那胺（TAF）（用于PEP）时的症状相似，导致其永久性停用PrEP：急性面部神经痛似乎是 FTC/TDF 罕见的特异性不良反应。

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Acute facial neuralgia related to initiation of emtricitabine/tenofovir for HIV PrEP: a report of two cases in a PrEP demonstration trial.

Background: Emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is generally well-tolerated, although treatment-related adverse events have been reported.

Methods: We report two cases of persons using FTC/TDF PrEP who had acute neuralgia in a Chinese PrEP demonstration trial.

Results: Neurological symptoms subsided upon treatment discontinuation. Symptoms were reported as similar to one case's previous experiences with dolutegravir (DTG)+FTC+tenofovir alafenamide (TAF) (for PEP), leading to permanent discontinuation of PrEP.

Conclusion: Acute facial neuralgia appears to be a rare idiosyncratic adverse event to FTC/TDF.

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来源期刊

Sexual health 医学-传染病学

CiteScore

2.30

自引率

12.50%

发文量

121

审稿时长

6-12 weeks

期刊介绍： Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence. Officially sponsored by: The Australasian Chapter of Sexual Health Medicine of RACP Sexual Health Society of Queensland Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.