Marlon Breno Zampieri Lima , Thuany Giovana Pereira Daniel , Hellen Tayaná Oliveira Bitencourt , Luiz Carlos Junior Alcantara , Rodrigo Haddad , Simone Kashima , Maria Carolina Elias , Marta Giovanetti , Sandra Coccuzzo Sampaio , Svetoslav Nanev Slavov
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引用次数: 0
摘要
最近有报道称,可以通过元基因组学方法在临床样本中检测到人类钩端螺旋体(GCYV)的遗传物质。然而,这些病毒对临床的潜在影响仍然未知。在这项研究中,我们评估了巴西亚马逊阿马帕州马卡帕市无症状献血者中 GCYV DNA 的分子流行率。2015 年,我们对 348 名无症状献血者的血浆样本进行了巢式 PCR 分子检测。在这些样本中,发现 6 份样本的 GYCV DNA 呈阳性(频率为 1.7%)。此外,还对阳性样本进行了扩增片段测序确认。目前,还没有关于 GCYV DNA 对健康捐献者和输血医学的影响的数据。全面的调查,包括更广泛的流行率研究,对于评估这些病毒在人群中的传播情况至关重要。此外,如果这种病毒存在潜在的临床影响,确定这种影响也至关重要。ABSTRACT 元基因组学最近发现,在临床样本中可以检测到钩端螺旋体病毒(GCYV)的基因组。然而,这些病毒对临床的潜在影响仍然未知。在这项研究中,我们评估了巴西亚马逊地区阿马帕州马卡帕市无症状献血者体内 GCYV DNA 的分子流行率。2015年期间,对348名无症状献血者的血浆样本进行了巢式PCR GYCV分子检测。其中,6 份样本的 GYCV DNA 检测呈阳性(流行率为 1.7%)。对阳性样本也进行了测序,以确认扩增子。目前还没有关于无症状献血者体内 GCYV DNA 影响的数据。进一步的研究,包括更广泛的流行率研究,对于评估这种病毒在人群中的传播情况至关重要。此外,确定这种病毒可能产生的临床影响(如果有的话)也至关重要。
期刊介绍:
Transfusion Clinique et Biologique, the official journal of the French Society of Blood Transfusion (SFTS):
- an aid to training, at a European level
- the only French journal indexed in the hematology and immunology sections of Current Contents
Transfusion Clinique et Biologique spans fundamental research and everyday practice, with articles coming from both sides. Articles, reviews, case reports, letters to the editor and editorials are published in 4 editions a year, in French or in English, covering all scientific and medical aspects of transfusion: immunology, hematology, infectious diseases, genetics, molecular biology, etc. And finally, a convivial cross-disciplinary section on training and information offers practical updates.
Readership:
"Transfusers" are many and various: anesthetists, biologists, hematologists, and blood-bank, ICU and mobile emergency specialists...