一名从不吸烟者的同步多发性神经内分泌原发性肺癌伴支气管内扩展--一种不寻常的表现形式

Vinay V, S. Munjal, J. Saini, Gaurav Kumar Singh, Shibani Modi, Alpana Srivastava
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摘要

同步肺癌原发灶(SLC)并不常见,基础组织学多样,只占很小一部分。这种稀缺性也给制定标准化诊断方法带来了挑战。因此,SLC 的诊断和分期面临更大的挑战,尤其是当肿瘤位于胸部两侧时。我们报告了同步多发性原发性肺癌中的一个罕见现象,即同时出现两种具有支气管内延伸的神经内分泌肿瘤--小细胞癌和典型类癌。免疫组化对确诊很有价值。鉴于此类病例预后较差,准确诊断对于确定适当的治疗方案至关重要。
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Synchronous multiple neuroendocrine primary lung cancer with endobronchial extension in a never smoker - An unusual manifestation
Synchronous Lung Cancer primaries (SLC) are uncommon, with diverse underlying histology, constituting only a small proportion. The scarcity also poses a challenge in formulating a standardized diagnostic approach. Consequently, the diagnostic and staging challenges for SLC are heightened, particularly when the tumors are located on opposite sides of the chest. We report an exceptionally rare phenomenon in synchronous multiple primary lung cancers with simultaneous occurrence of two neuroendocrine tumors with endobronchial extension, small cell carcinoma and typical carcinoid tumor. Immunohistochemistry proved valuable in confirming the diagnosis. Given the poor prognosis associated with such cases, an accurate diagnosis is crucial for determining appropriate treatment options.
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