天然制剂的龋齿消毒及其功效:最新文献综述

Sreejeeta Dey, S. Deshmukh
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引用次数: 0

摘要

龋洞下残留的细菌数量会改变牙齿修复的成功率,随着时间的推移,微渗漏或二次龋坏会导致粘接剂变质。在龋洞壁上涂抹龋洞消毒剂可以起到清洁作用,减少细菌负荷,延长修复体的寿命。虽然这类化学消毒剂种类繁多,但由于其细胞毒性作用,天然制剂越来越受欢迎。这些材料具有抗菌、抗氧化和消炎的特性,可以有效地消毒龋洞壁,同时成本更低、毒性更小、对患者更友好。其中一些制剂还被证明可以通过防止胶原降解和抑制 MMP 来提高树脂与牙本质的粘结强度。蜂胶、芦荟、壳聚糖、绿茶、甘草等提取自植物或动物的部分,经测试具有良好的疗效,在某些情况下优于化学替代品,且不会对牙本质产生任何侵蚀作用。本综述旨在强调几种此类天然制剂作为潜在龋齿消毒剂的特性和有效性。
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Cavity Disinfection with Natural Agents and their Efficacy: A Review on Recent Literature
The success of a dental restoration can be altered by the amount of residual bacteria present under the cavity which over time cause deterioration of adhesive cement by microleakage or secondary caries. Cavity disinfectant application on the cavity walls performs a cleansing ac-tion to decrease the bacterial load and improve the longevity of restorations. Although a wide variety of such chemical disinfectants have been in use, their cytotoxic effects have led to the increasing popularity of natural agents. These materials possess antimicrobial, antioxidant and anti-inflammatory properties, which effectively disinfect cavity walls while, at the same time, being cheaper, less toxic, and more patient-friendly. Some of these agents have also been proven to improve the bond strength of resin to dentin by preventing collagen degradation and MMP inhibition. Propolis, aloe vera, chitosan, green tea, liquorice etc., are derived from parts of plants or animals and have been tested to be efficacious and, in some cases, superior to chemical alternatives without any erosive effect on dentin. Although there is a lack of enough in-vivo evidence to advocate the use of these products as an adjunct in dental therapy, recent studies have yielded promising results, which increases the scope for future clinical research. This review aims to highlight the properties and effectiveness of a few of such natural agents as potential cavity disinfectants.
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来源期刊
Anti-Infective Agents
Anti-Infective Agents Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
1.50
自引率
0.00%
发文量
47
期刊介绍: Anti-Infective Agents publishes original research articles, full-length/mini reviews, drug clinical trial studies and guest edited issues on all the latest and outstanding developments on the medicinal chemistry, biology, pharmacology and use of anti-infective and anti-parasitic agents. The scope of the journal covers all pre-clinical and clinical research on antimicrobials, antibacterials, antiviral, antifungal, and antiparasitic agents. Anti-Infective Agents is an essential journal for all infectious disease researchers in industry, academia and the health services.
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