用于治疗 COVID-19 的心脏毒性药物

A. S. Zmitrukevich, A. E. Mamedova
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摘要

背景。COVID-19大流行是由SARS-CoV-2病毒引起的。目的:简要报告治疗 COVID-19 的常用药物对心血管系统的影响。简要报告治疗 COVID-19 的常用药物对心血管系统的影响。各种药物已被用于治疗COVID-19。最常见的药物包括羟氯喹、雷米替韦、法非吡韦、氟喹诺酮类、干扰素-α2b、糖皮质激素、莫鲁吡韦和利托那韦/奈马曲韦。大多数药物都会引起心血管系统的变化,尤其是 QT 间期的变化。医生在治疗 COVID-19 时应考虑到所有药物的潜在心脏毒性。治疗师和全科医生在治疗COVID-19患者时应注意心血管风险,并对人群进行预防性体检。
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Cardiotoxic Drugs Used in the Treatment of COVID-19
Background. The COVID-19 pandemic is caused by the SARS-CoV-2 virus. Insufficient attention is paid to the cardiotoxic potential of the drugs used in the treatment of COVID-19.Aim. A brief report on the effect of the drugs commonly used in the treatment of COVID-19 on the cardiovascular system.Discussion. Various medications have been used to treat COVID-19. Some of the most common drugs include hydroxychloroquine, remdesvir, favipiravir, fluoroquinolones, interferon-α2b, glucocorticoids, molnupiravir, and ritonavir/nirmatrelvir. Most medications can cause changes in the cardiovascular system, especially in the QT interval.Conclusions. Physicians should take into account the cardiotoxic potential of all medications used in the treatment of COVID-19. Therapists and general practitioners should be aware of cardiovascular risks in the management of patients with COVID-19, as well as the prophylactic medical examinations of the population.
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