临床分离物中各种细菌对可乐定和其他抗生素的敏感性分析

Sreeja Vamsi Kogila, Sravanthi Brungi, Ramavath Usha Rani, Bhumireddy Rama Chandra Reddy
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摘要

本研究旨在确定从泰兰加纳地区医院重症监护室病人的各种临床样本中分离出的革兰氏阴性杆菌对可乐定的敏感性,并与其他抗生素进行比较。本研究使用临床病原体分离物进行药敏试验。共对 1852 株连续分离的革兰氏阴性菌进行了可乐定药敏试验。所有细菌分离物(如、、、和)均包括在内。采用肉汤微稀释法检测所有耐药菌株的抗生素最低抑菌浓度(MIC)。据观察,在......和......中,耐药性相当显著,而在所研究的其他细菌种类(即......、......、......和......)中,耐药性则不太显著。耐药性表明,迫切需要通过采取适当措施来控制目前的情况,以减缓特兰干纳州革兰氏阴性细菌中抗生素耐药性的发展。在南印度,有关可乐定耐药性的临床数据非常缺乏。这项研究是为数不多的能说明该地区革兰氏阴性细菌耐药性现状的研究之一。
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Susceptibility analysis of various bacteria towards colistin and other antibiotics in clinical isolates
This study aimed to determine the susceptibility of Gram-negative bacilli isolated from various clinical samples of patients admitted to ICUs of hospitals in Telangana region against colistin and compared with other antibiotics. In the present study clinical pathogen isolates were used for the susceptibility test. A total of 1852 consecutive Gram-negative isolates were tested for Colistin susceptibility. All the bacterial isolates of (e.g., , ), and were included. All Colistin resistant isolates were processed to detect the minimum inhibitory concentration (MIC) of antibiotics by the broth micro-dilution method. It was observed that in . and the susceptibility was quite significant whereas it was not much significant for other species of bacteria studied namely, , , , and . . and resistance indicated that there is an argent need to get the current situation under control by implementing appropriate measures to slow down the progression of antibiotic resistance in gram-negative bacteria in Telangana. and showed significant resistance to Colistin compared with other antibiotics than other gram-negative bacilli isolated from various clinical samples. There is a shortage of clinical data available in South India regarding the prevalence of colistin resistance. This study is one of the few studies that indicate the current scenario of resistance of gram-negative bacteria in this particular area.
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