{"title":"SLU-PP-332 \"作为一种有效的减肥药，具有间接保护肾脏的功效；肾脏病学视角下的新希望","authors":"Hamid Nasri","doi":"10.34172/jre.2024.25143","DOIUrl":null,"url":null,"abstract":"SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen receptor-related orphan receptor target gene, and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"26 7","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New hopes on \\\"SLU-PP-332\\\" as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view\",\"authors\":\"Hamid Nasri\",\"doi\":\"10.34172/jre.2024.25143\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen receptor-related orphan receptor target gene, and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.\",\"PeriodicalId\":16964,\"journal\":{\"name\":\"Journal of Renal Endocrinology\",\"volume\":\"26 7\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Renal Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/jre.2024.25143\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Renal Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/jre.2024.25143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
New hopes on "SLU-PP-332" as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view
SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen receptor-related orphan receptor target gene, and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.
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