加纳沃尔特地区接种疫苗前的 SARS-CoV-2 抗体血清流行率

IF 1.5 Q4 INFECTIOUS DISEASES IJID regions Pub Date : 2024-01-20 DOI:10.1016/j.ijregi.2024.01.007

Enoch Aninagyei , Reuben Ayivor-Djanie , Jones Gyamfi , Marfo Edward Aboagye , Grace Semabia Kpeli , William Kwabena Ampofo , John Owusu Gyapong , Kwabena Obeng Duedu

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引用次数: 0

摘要

目标在加纳沃尔特地区首府对选定的优先群体接种第一剂阿斯利康 2019 SARS-CoV-2 疫苗之前，我们确定了潜在接种者的接种前状况，并在报告首例病例 1 年后确定了基线暴露状况。方法在获得知情同意后，采集血液样本，使用快速诊断试剂盒检测 SARS-CoV-2 免疫球蛋白 (Ig) M/IgG 抗体。共有 409 人（平均年龄 27 岁）同意并参与了研究，其中 70% 为学生，其他为前来接种疫苗的医务人员和教育工作者。结果 SARS-CoV-2 的总体暴露率为 12.7%（95% 置信区间 [CI] 9.6-16.3）。SARS-CoV-2 IgM 和 IgG 的感染率分别为 4.2% (95% CI 2.4-6.6) 和 5.6% (95% CI 3.6-8.3)。2.9%（95% CI 1.5-5.1）的受访者检测到 IgM 和 IgG。40 岁以上参与者的感染率更高（15.5%）。没有COVID-19类似症状病史的受访者的接触率为13.0%，没有任何慢性疾病的受访者的接触率为13.2%。

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Pre-vaccination seroprevalence of SARS-CoV-2 antibodies in the Volta Region, Ghana

Objectives

Before administration of the first dose of the AstraZeneca 2019 SARS-CoV-2 vaccine to selected prioritized groups in the Volta regional capital of Ghana, we determined the pre-vaccination status of prospective recipients and established the baseline exposure status 1 year after the first case was reported.

Methods

After informed consent, blood samples were collected for the detection of SARS-CoV-2 immunoglobulin (Ig) M/IgG antibodies using rapid diagnostic test kits. A total of 409 individuals (mean age 27 years) consented and participated in the study, comprising 70% students and others were health staff and educators who presented themselves for vaccination.

Results

The overall exposure rate of SARS-CoV-2 was 12.7% (95% confidence interval [CI] 9.6-16.3). The prevalence of SARS-CoV-2 IgM and IgG were 4.2% (95% CI 2.4-6.6) and 5.6% (95% CI 3.6-8.3), respectively. IgM and IgG were detected in 2.9% (95% CI 1.5-5.1) of the respondents. The exposure rates were higher in participants over 40 years old (15.5%). Participants without a history of COVID-19–like symptoms had an exposure rate of 13.0% and those without any chronic diseases was 13.2%.