Tatiana N. Nekrasova, Andrei I. Fischer, Natalia A. Nesterova, Anatoliy V. Dobrodumov, Anzhelika V. Garshinina, Olga D. Shuvaeva, Natalya V. Zakharova, Evgenii F. Panarin
{"title":"设计具有生物活性的大分子配体及其与铽离子的发光复合物","authors":"Tatiana N. Nekrasova, Andrei I. Fischer, Natalia A. Nesterova, Anatoliy V. Dobrodumov, Anzhelika V. Garshinina, Olga D. Shuvaeva, Natalya V. Zakharova, Evgenii F. Panarin","doi":"10.1007/s10118-024-3081-0","DOIUrl":null,"url":null,"abstract":"<div><p>Water-soluble copolymers of p-methacrylamidobenzoic acid (MABA) with neutral comonomers (<i>N</i>-vinylpyrrolidone (VP), <i>N</i>-methyl-<i>N</i>-vinylacetamide (MVAA), <i>N</i>-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb<sup>3+</sup> ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb<sup>3+</sup> complexes with the copolymers was revealed. The luminescence intensity of Tb<sup>3+</sup> complexes with the copolymers containing <i>N</i>-vinylamide units (VP, MVAA) is three times more intense than that observed for the complexes between Tb<sup>3+</sup> and MAG-containing copolymers. In the case of NaSS-containing copolymers, the luminescence intensity is controlled by the values of binding constants between Tb<sup>3+</sup> and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb<sup>3+</sup> have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.</p></div>","PeriodicalId":517,"journal":{"name":"Chinese Journal of Polymer Science","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions\",\"authors\":\"Tatiana N. Nekrasova, Andrei I. Fischer, Natalia A. Nesterova, Anatoliy V. Dobrodumov, Anzhelika V. Garshinina, Olga D. Shuvaeva, Natalya V. Zakharova, Evgenii F. Panarin\",\"doi\":\"10.1007/s10118-024-3081-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Water-soluble copolymers of p-methacrylamidobenzoic acid (MABA) with neutral comonomers (<i>N</i>-vinylpyrrolidone (VP), <i>N</i>-methyl-<i>N</i>-vinylacetamide (MVAA), <i>N</i>-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb<sup>3+</sup> ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb<sup>3+</sup> complexes with the copolymers was revealed. The luminescence intensity of Tb<sup>3+</sup> complexes with the copolymers containing <i>N</i>-vinylamide units (VP, MVAA) is three times more intense than that observed for the complexes between Tb<sup>3+</sup> and MAG-containing copolymers. In the case of NaSS-containing copolymers, the luminescence intensity is controlled by the values of binding constants between Tb<sup>3+</sup> and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb<sup>3+</sup> have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.</p></div>\",\"PeriodicalId\":517,\"journal\":{\"name\":\"Chinese Journal of Polymer Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-01-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Polymer Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10118-024-3081-0\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10118-024-3081-0","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions
Water-soluble copolymers of p-methacrylamidobenzoic acid (MABA) with neutral comonomers (N-vinylpyrrolidone (VP), N-methyl-N-vinylacetamide (MVAA), N-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb3+ ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb3+ complexes with the copolymers was revealed. The luminescence intensity of Tb3+ complexes with the copolymers containing N-vinylamide units (VP, MVAA) is three times more intense than that observed for the complexes between Tb3+ and MAG-containing copolymers. In the case of NaSS-containing copolymers, the luminescence intensity is controlled by the values of binding constants between Tb3+ and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb3+ have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.
期刊介绍：
Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985.
CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.
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