Modawy Em Elkhalifa, Muhammad Ashraf, Alshebli Ahmed, Assad Usman, Alashary Ae Hamdoon, Mohammed A Elawad, Meshari G Almalki, Osama F Mosa, Laziz N Niyazov, Muhammad Ayaz
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引用次数: 0
摘要
耐多药(MDR)病原体的出现是传染病治疗管理中的一个主要问题。细菌的抗药性机制之一是形成一种被称为生物膜的包膜蛋白和多糖水合基质。多酚类化合物具有有益的抗菌作用。酚类化合物通过破坏细菌膜、剥夺底物、蛋白质结合、与粘附复合物结合、病毒融合阻断以及与真核 DNA 相互作用来发挥抗生物膜作用。然而,这些化合物存在化学性质不稳定、生物利用率低、水溶性差和半衰期短等局限性。纳米制剂通过增强其抗菌潜力,为克服这些挑战提供了一种前景广阔的解决方案。本综述总结了多酚类化合物的抗生物膜作用、其基本机制以及作为抗性调节剂的潜在作用。
Polyphenols and their nanoformulations as potential antibiofilm agents against multidrug-resistant pathogens.
The emergence of multidrug-resistant (MDR) pathogens is a major problem in the therapeutic management of infectious diseases. Among the bacterial resistance mechanisms is the development of an enveloped protein and polysaccharide-hydrated matrix called a biofilm. Polyphenolics have demonstrated beneficial antibacterial effects. Phenolic compounds mediate their antibiofilm effects via disruption of the bacterial membrane, deprivation of substrate, protein binding, binding to adhesion complex, viral fusion blockage and interactions with eukaryotic DNA. However, these compounds have limitations of chemical instability, low bioavailability, poor water solubility and short half-lives. Nanoformulations offer a promising solution to overcome these challenges by enhancing their antibacterial potential. This review summarizes the antibiofilm role of polyphenolics, their underlying mechanisms and their potential role as resistance-modifying agents.
期刊介绍:
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.