{"title":"肥胖症是一种三重流行病,是价值万亿美元的疾病:预防是当务之急","authors":"Hilary Hoey , Edna Roche","doi":"10.1016/j.gpeds.2024.100141","DOIUrl":null,"url":null,"abstract":"<div><p>Obesity is a major global preventable condition. The prevalence in children and adolescents is high and increasing globally.</p><p>It is associated with serious complications and very expensive morbidity. These include the metabolic syndrome, type 2 diabetes which is more aggressive in children than in adults and an increased prevalence of cancer. In addition, obstetric complications occur along with the development of a cycle of obesity associated with trans generational epigenetic changes associated with obese infants leading to obesity in childhood and later life.</p><p>The management and treatment of obesity is difficult including <strong>c</strong>hanges in established life style. Medications for children are limited and surgery is invasive, generally irreversible and requires lifelong nutritional support. There is a paucity of long-term outcome data relating to both medications and surgery.</p><p>Prevention at all ages is imperative particularly during the first 1000 days of life, during adolescence and in those who have predisposing factors relating to type 2 diabetes. It requires national governments, communities and health services to promote diet, exercise, early childhood care, school health and expert weight management services.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"7 ","pages":"Article 100141"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000095/pdfft?md5=4d28a575127da9e8d463a7f7524299b0&pid=1-s2.0-S2667009724000095-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Obesity a triple pandemic, the trillion dollar disease: Prevention is imperative\",\"authors\":\"Hilary Hoey , Edna Roche\",\"doi\":\"10.1016/j.gpeds.2024.100141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Obesity is a major global preventable condition. The prevalence in children and adolescents is high and increasing globally.</p><p>It is associated with serious complications and very expensive morbidity. These include the metabolic syndrome, type 2 diabetes which is more aggressive in children than in adults and an increased prevalence of cancer. In addition, obstetric complications occur along with the development of a cycle of obesity associated with trans generational epigenetic changes associated with obese infants leading to obesity in childhood and later life.</p><p>The management and treatment of obesity is difficult including <strong>c</strong>hanges in established life style. Medications for children are limited and surgery is invasive, generally irreversible and requires lifelong nutritional support. There is a paucity of long-term outcome data relating to both medications and surgery.</p><p>Prevention at all ages is imperative particularly during the first 1000 days of life, during adolescence and in those who have predisposing factors relating to type 2 diabetes. It requires national governments, communities and health services to promote diet, exercise, early childhood care, school health and expert weight management services.</p></div>\",\"PeriodicalId\":73173,\"journal\":{\"name\":\"Global pediatrics\",\"volume\":\"7 \",\"pages\":\"Article 100141\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667009724000095/pdfft?md5=4d28a575127da9e8d463a7f7524299b0&pid=1-s2.0-S2667009724000095-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667009724000095\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667009724000095","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Obesity a triple pandemic, the trillion dollar disease: Prevention is imperative
Obesity is a major global preventable condition. The prevalence in children and adolescents is high and increasing globally.
It is associated with serious complications and very expensive morbidity. These include the metabolic syndrome, type 2 diabetes which is more aggressive in children than in adults and an increased prevalence of cancer. In addition, obstetric complications occur along with the development of a cycle of obesity associated with trans generational epigenetic changes associated with obese infants leading to obesity in childhood and later life.
The management and treatment of obesity is difficult including changes in established life style. Medications for children are limited and surgery is invasive, generally irreversible and requires lifelong nutritional support. There is a paucity of long-term outcome data relating to both medications and surgery.
Prevention at all ages is imperative particularly during the first 1000 days of life, during adolescence and in those who have predisposing factors relating to type 2 diabetes. It requires national governments, communities and health services to promote diet, exercise, early childhood care, school health and expert weight management services.