Global pediatrics最新文献

{"title":"Mitigating adverse effects of antiseizure medications in pediatric drug-resistant epilepsy: an open-label single-arm study of adjunctive Epilamba®","authors":"Antonella Riva ,&nbsp;Andrea Tagliaferri ,&nbsp;Filippo Affaticati ,&nbsp;Martina Giorgia Perinelli ,&nbsp;Mattia Grasso ,&nbsp;Alice Dainelli ,&nbsp;Vincenzo Belcastro ,&nbsp;Agostino Bruno ,&nbsp;Gabriele Costantino ,&nbsp;Pasquale Striano","doi":"10.1016/j.gpeds.2026.100320","DOIUrl":"10.1016/j.gpeds.2026.100320","url":null,"abstract":"<div><h3>Background</h3><div>Managing the adverse effects associated with anti-seizure medications (ASMs) is essential for enhancing the quality of life and adherence to treatment in children with drug-resistant epilepsy. This study evaluated the potential of Epilamba®, a food supplement, in mitigating treatment-related adverse effects.</div></div><div><h3>Methods</h3><div>Pediatric patients with drug-resistant epilepsy on polytherapy were enrolled to receive adjunctive Epilamba® (1 sachet/day) for six months. Assessments of seizure frequency, systemic and neurological toxicity, and gastrointestinal symptoms were conducted using standardized questionnaires at baseline (T0), three months (T1), and six months (T2). Data were analyzed using the Wilcoxon signed-rank test, with significance set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Twenty-five children (mean age 9.84±4.39 years) completed the study. No significant changes were observed in seizure frequency or semiology from baseline at either T1 (<em>p</em> = 0.42) or T2 (<em>p</em> = 0.23), indicating that Epilamba® did not interfere with ASM effectiveness. Systemic toxicity significantly improved at T1 (<em>p</em> = 0.008) and T2 (<em>p</em> = 0.02) compared to baseline, though no additional improvement was observed between T1 and T2 (<em>p</em> = 0.62). Neurotoxicity also significantly decreased at T1 (<em>p</em> = 0.009) and T2 (<em>p</em> = 0.02), with stabilization thereafter (T1 vs. T2, <em>p</em> = 0.6). Gastrointestinal symptoms, present in over 40% of participants at baseline, showed significant improvement only at T2 (<em>p</em> = 0.04).</div></div><div><h3>Conclusions</h3><div>Epilamba® appears effective in reducing anti-seizure medications-related adverse effects in children with drug-resistant epilepsy, with peak benefits observed within three months of treatment, maintained during the follow-up, and without compromising seizure control. Further studies may contribute to assessing the effects of Epilamba® as adjunctive therapy in pediatric drug-resistant epilepsy management.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100320"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of rehabilitation needs, utilization patterns, and out-of-pocket costs among children with disabilities: evidence from a national survey","authors":"Jae Eun Yang ,&nbsp;Ah Rim Kim","doi":"10.1016/j.gpeds.2026.100321","DOIUrl":"10.1016/j.gpeds.2026.100321","url":null,"abstract":"<div><div>This study examined predictors of rehabilitation therapy needs, utilization time, and out-of-pocket (OOP) costs among children with disabilities in South Korea. We conducted a cross-sectional secondary analysis using data from the 2020 National Survey of the Disabled, including 338 children under 18 years of age. Rehabilitation needs, weekly therapy duration, and OOP costs were analyzed using descriptive statistics, chi-square tests, and logistic regression, with duration- and cost-related analyses restricted to the subsample of 250 children currently receiving therapy. Rehabilitation needs were significantly associated with brain lesions, speech disabilities, and receipt of housing benefits. Younger age, greater disability severity, higher household income, and stronger family support were related to longer weekly therapy duration. Average monthly OOP expenditures were 186 640 KRW, with higher costs linked to increased utilization, higher income, better home accessibility, and greater perceived discrimination, while lower satisfaction with welfare projects was associated with higher costs. Logistic regression identified brain lesions (OR 7.63), speech disabilities (OR 2.44), and housing benefit receipt (OR 3.28) as strong predictors of rehabilitation needs. Despite limitations in survey weighting and measurement, these findings highlight substantial socioeconomic and disability-related disparities in rehabilitation access and financial burden. Policy efforts are needed to reduce inequities, strengthen family-centered multidisciplinary rehabilitation services, and expand equitable access for children with disabilities and their families.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100321"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and neonatal morbidities associated with preterm birth: A three-year retrospective study at Ekiti State University Teaching Hospital, Nigeria","authors":"Deborah Tolulope Esan ,&nbsp;Deborah Sewanu Alivide ,&nbsp;Basil PerfectGodsgift Nmamdi ,&nbsp;Adetumise Oluseyi Olajide ,&nbsp;Ayodeji Olubunmi Ogunmuyiwa ,&nbsp;Blessed Obem Oyama ,&nbsp;Timothy Kayode Samson ,&nbsp;Carlos Guillermo Ramos","doi":"10.1016/j.gpeds.2026.100319","DOIUrl":"10.1016/j.gpeds.2026.100319","url":null,"abstract":"<div><h3>Background</h3><div>Preterm delivery represents a critical public health challenge as the primary cause of infant mortality and significant morbidity among survivors. This retrospective study examined preterm birth prevalence and associated complications at Ekiti State University Teaching Hospital, Nigeria.</div></div><div><h3>Methods</h3><div>Medical records of pregnant women receiving antenatal care and delivering between 2019–2021 were analyzed. Data included maternal characteristics, obstetric history, and neonatal outcomes, with descriptive statistics used for analysis. To assess the significance of the associations, between categorical variables, inferential statistical analyses were conducted using Chi-square test. The statistical significance was set at <em>p</em> &lt; .05.</div></div><div><h3>Results</h3><div>The distribution of neonatal morbidities across selected maternal demographic variables showed significant variation by year of delivery (<em>p</em> &lt; .05), with higher prevalence among married women, Christians, and parents with tertiary education (<em>p</em> &lt; .05). Preterm birth prevalence declined significantly over the years: 20.9 % in 2019, 10.2 % in 2020, and 8.2 % in 2021 (χ² = 30.42, <em>p</em> &lt; .001), indicating a downward trend and a corresponding increase in term deliveries. Maternal factors significantly associated with preterm birth included parity (<em>p</em> &lt; .001), gestational age at booking (<em>p</em> = .042), previous cesarean section (<em>p</em> = .029), history of pregnancy-induced hypertension (<em>p</em> &lt; .001), antepartum hemorrhage (<em>p</em> &lt; .001), pre-eclampsia (<em>p</em> &lt; .001), and eclampsia (<em>p</em> &lt; .001). Most cases occurred among multiparous women (parity 1–4), those booking at ≤20 weeks gestation, and those with histories of pregnancy-induced hypertension or pre-eclampsia. Neonatal variables showed significant variations by year in birth weight (χ² = 180.32, <em>p</em> &lt; .001) and mode of delivery (χ² = 282.28, <em>p</em> &lt; .001), but not in sex (<em>p</em> = .999) or gestation type (<em>p</em> = .693). All reported morbidities (jaundice, fever, anemia, convulsion, and birth defects) were significantly associated with preterm birth (<em>p</em> &lt; .05), with higher prevalence in these conditions.</div></div><div><h3>Conclusion</h3><div>Preterm birth prevalence declined significantly from 2019 to 2021, alongside variations in neonatal morbidities influenced by maternal demographics and obstetric factors. Targeted interventions addressing modifiable risk factors, such as early booking and management of hypertensive disorders, could further reduce preterm births and associated morbidities in similar settings.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100319"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical instructors performance in radiographic assessment of primary molar furcation areas: A pilot study","authors":"Hyun-Joo Lim ,&nbsp;Rojin Adabdokht ,&nbsp;Hollis Lai,&nbsp;Manuel O. Lagravere Vich,&nbsp;Camila Pacheco-Pereira,&nbsp;Naeem Hedayatipoor,&nbsp;Ida Kornerup","doi":"10.1016/j.gpeds.2025.100317","DOIUrl":"10.1016/j.gpeds.2025.100317","url":null,"abstract":"<div><h3>Purpose and Background</h3><div>This study aimed to evaluate the diagnostic performance, agreement, and consistency of pediatric dentistry instructors in radiographic diagnosis of furcation lesions. Radiographic identification of furcation lesions in primary molars is challenging due to the superimposition of anatomic features and the developing permanent tooth buds. Clinical instructors’ inconsistencies in diagnosing this lesion may compromise patient outcomes and student training.</div></div><div><h3>Methods</h3><div>Eight clinical instructors assessed 20 radiographs in two blinded rounds. A validated reference diagnosis dataset was established by two calibrated specialists, using paired pre-treatment and follow-up radiographs. Total and subgroup analysis was performed between instructors with and without specialty training. Diagnostic performance was measured by sensitivity, specificity, and accuracy. Agreement and consistency were evaluated using Fleiss’ and Cohen’s Kappa.</div></div><div><h3>Results</h3><div>Overall sensitivity, specificity, and accuracy were 0.75, 0.77, and 0.76, respectively, with no significant differences between pediatric specialists and general dentists (<em>p</em> = 0.79). Agreement was moderate overall (<em>K</em> = 0.50 - 0.59), ranging from fair to moderate in general dentists and substantial in specialists. Intra-rater consistency was substantial to almost perfect overall and in both groups (<em>K</em> = 0.62- 0.82).</div></div><div><h3>Conclusions</h3><div>Instructors demonstrated satisfactory accuracy and high intra-rater consistency in diagnosing furcation lesions, however inter-rater agreement was suboptimal. Standardized guidelines or could improve calibration and teaching reliability.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-related breathing disorders (SRBD) and attention-deficit/hyperactivity disorder (ADHD) in children attending an orthodontic clinic: a pilot case-control study","authors":"Marie Laurent ,&nbsp;Adelin Albert ,&nbsp;Matthieu Thimmesch ,&nbsp;Anne-Lise Poirrier ,&nbsp;Annick Bruwier","doi":"10.1016/j.gpeds.2025.100318","DOIUrl":"10.1016/j.gpeds.2025.100318","url":null,"abstract":"<div><h3>Introduction</h3><div><strong>:</strong> Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children. Sleep-related breathing disorders (SRBD), often caused by craniofacial abnormalities narrowing the airway, may be associated with ADHD. Therefore, orthodontists involved in the diagnosis and the treatment of sleep disorders should also be concerned by ADHD. The primary objective of this study was to explore the association between SRBD and ADHD in children referred to an orthodontic clinic. The study also investigated cephalometric characteristics in these children.</div></div><div><h3>Material and Methods</h3><div><strong>:</strong> This pilot case-control study included 22 children attending an orthodontic clinic: 11 ADHD children diagnosed by a neuropsychologist and 11 control children matched for age, gender, BMI, and ethnicity. Control subjects were free of ADHD according to DSM-V classification. Type 3 ventilator polygraphy and cephalometric radiographs were performed. Parents answered the pediatric sleep questionnaire regarding SRBD symptoms of their child (PSQ-SRBD). A severity score and a restricted version of it removing 6 questions on behaviour were calculated. Both scores range from 0 to 1 with high values indicative of SRBD.</div></div><div><h3>Results</h3><div><strong>:</strong> ADHD children evidenced a higher PSQ-SRBD severity score than controls (0.50 ± 0.14 vs. 0.11 ± 0.11, mean difference 0.39 ± 0.16, <em>p</em> &lt; 0.0001) and similarly for the restricted score (0.33 ± 0.17 vs. 0.058 ± 0.056, mean difference 0.37 ± 0.17, <em>p</em> = 0.0003). Ventilator polygraphy parameters although not significantly different between groups were always higher in ADHD children (e.g. ventilatory effort 17.3 ± 7.0 vs 14.5 ± 12.3%; sleep fragmentation 14.5 ± 4.8 vs 13.5 ± 7.3 micro-arousals/h). Cephalometric features were comparable but ADHD subjects showed more mandibular deviation to the left (<em>p</em> = 0.032).</div></div><div><h3>Conclusion</h3><div><strong>:</strong> Children with ADHD were more likely to suffer from sleep-related breathing disorders according to the PSQ-SRBD severity score, although the polygraph results did not confirm this finding. As for craniofacial anomalies, they only showed more mandibular deviation to the left. ADHD is important in pediatric, ENT and orthodontic practice to manage treatment of children optimally.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100318"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of pediatric invasive pneumococcal disease in an inner-city tertiary care center: A 13-year study and post-pandemic insights","authors":"Sarah Habbal ,&nbsp;Nahed Abdel-Haq ,&nbsp;Basim Asmar ,&nbsp;Ronald Thomas ,&nbsp;Jocelyn Yu Ang","doi":"10.1016/j.gpeds.2025.100316","DOIUrl":"10.1016/j.gpeds.2025.100316","url":null,"abstract":"<div><h3>Background</h3><div>Invasive pneumococcal disease (IPD) remains a significant cause of morbidity and mortality in children. While global IPD incidence declined during the COVID-19 pandemic due to mitigation measures, a resurgence followed the relaxation of these interventions.</div></div><div><h3>Objectives</h3><div>The primary objective is to describe the epidemiology of IPD at our institution after the introduction of PCV-13 and to compare trends before and after the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A retrospective chart review of IPD patients ≤21 years of age admitted between January 2010 - February 2024 at the Children’s Hospital of Michigan, Detroit. Patients were further categorized into 2 groups: pre-pandemic (2016-2020) and pandemic/post-pandemic (2020-2024).</div></div><div><h3>Results</h3><div>143 cases were included. IPD incidence decreased during the pandemic (2020-2021) to 0.6-0.8 per 1000 hospital admissions but rebounded in 2022-2023 to 1.7-1.4 per 1,000 hospital admissions. Of 143 patients 99/143(69 %) had no known risk factor and 12/143 (8.3 %) had sickle cell disease. 73 % (90/143) were fully immunized. Pneumococcal antibodies were tested in 37 patients and 20/37(54 %) had low titers; 16/20 (80 %) were fully immunized. No statistically significant differences were observed between the two periods regarding age, gender, clinical presentation or clinical outcome (<em>p</em> = &gt;0.05). However, the proportion of unimmunized children was significantly higher in the post-pandemic period (<em>n</em> = 8/43, 20.5 %) compared to pre-pandemic period (<em>n</em> = 2/49, 4.8 %; <em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>IPD incidence increased during the two years post COVID-19 pandemic, potentially due to decreased vaccination. Recognizing these epidemiological shifts and addressing vaccination gaps with use of updated vaccine are critical in preventing future IPD outbreaks.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of scabies among school-age children in selected public primary schools of Debre Tabor town, Northwest Ethiopia: A cross-sectional study, 2023","authors":"Meron Wolanewos Asfaw ,&nbsp;Bacha Mirkena Dhabi ,&nbsp;Tsion Wolanewos Asfaw ,&nbsp;Betelhem Alemu Mulugeta ,&nbsp;Ephrem Mamo Gebrehiwot","doi":"10.1016/j.gpeds.2025.100315","DOIUrl":"10.1016/j.gpeds.2025.100315","url":null,"abstract":"<div><h3>Background</h3><div>Scabies is a parasitic skin infestation affecting all ages worldwide and is classified as a neglected tropical disease. Poverty and poor hygiene drive its spread. Despite national control strategies, scabies remains prevalent in Ethiopia, yet data on its burden and risk factors among school children in Debre Tabor town are limited.</div></div><div><h3>Objective</h3><div>To assess the prevalence and determinants of scabies among school-age children in selected public primary schools in Debre Tabor town, Northwest Ethiopia.</div></div><div><h3>Methods</h3><div>Institution‑based cross‑sectional study was conducted May 5–30, 2023, among 302 school‑age children randomly selected from five primary schools. Data were collected via structured questionnaire and physical examination, with quality assured through pretesting and supervision. Entries were made in Epi‑data 4.6 and analyzed in SPSS 24. Variables with <em>p-value &lt; 0.25</em> in bivariate analysis entered multivariate logistic regression. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were reported, with significance at <em>p-value &lt; 0.05</em>.</div></div><div><h3>Results</h3><div>The prevalence of scabies was 12.3 % (95 % CI: 9.3 %, 17.2 %). Significant factors included family size &gt;5 (AOR = 4.2, 95 % CI: 1.20–16.35), unimproved water source (AOR = 5.3, 95 % CI: 1.38–20.22), handwashing with water only (AOR = 4.8, 95 % CI: 1.22–18.66), sharing clothes (AOR = 3.7, 95 % CI: 1.05–13.31), bed sharing (AOR = 6.5, 95 % CI: 1.40–30.50) and traveling ≥30 min to fetch water (AOR = 4.9, 95 % CI: 1.15–21.09)</div></div><div><h3>Conclusion</h3><div>Scabies prevalence among school-age children in Debre Tabor was high, driven by household crowding, poor hygiene, and limited water. Targeted interventions in hygiene education, safe water, and behavioral change are essential.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100315"},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on implementation and use of caffeine in Ethiopia","authors":"Gesit Metaferia ,&nbsp;Mahlet Abayneh ,&nbsp;Asrat Demtse ,&nbsp;Hailu Berta ,&nbsp;Bogale Worku ,&nbsp;Daniele Trevisanuto ,&nbsp;Corrado Moretti ,&nbsp;Camilla Gizzi","doi":"10.1016/j.gpeds.2025.100314","DOIUrl":"10.1016/j.gpeds.2025.100314","url":null,"abstract":"<div><div>Methylxanthines such as caffeine and aminophylline are routinely administered to prevent apnea of prematurity. Caffeine is one of the most extensively studied drugs in neonatology and, for this reason, it has been included in the World Health Organization’s list of essential medicines since 2009. Unfortunately, caffeine is still not available in many low-resource settings. In Ethiopia, its introduction has begun, but national recommendations are still lacking.</div><div>In this manuscript, we present the process and results of an international expert consensus on the use of caffeine for the prevention and treatment of apnea of prematurity, aimed at supporting its implementation as an essential drug in Ethiopian hospitals. The article's influence may extend beyond Ethiopia, serving as a model for other low- and middle-income countries seeking to integrate caffeine into their neonatal care protocols.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100314"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisystem Inflammatory Syndrome in Children (MIS-C): A clinical and research overview in the framework of a personalized medicine approach","authors":"Francesca Scaltrito ,&nbsp;Maria Teresa Grimaldi ,&nbsp;Grazia Tolfa ,&nbsp;Roberta De Benedetto ,&nbsp;Domenico Adduce ,&nbsp;Maria Pastore ,&nbsp;Sara Cannito ,&nbsp;Ida Giardino ,&nbsp;Massimo Pettoello-Mantovani","doi":"10.1016/j.gpeds.2025.100313","DOIUrl":"10.1016/j.gpeds.2025.100313","url":null,"abstract":"<div><div>Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe pediatric condition first identified in Europe and the United States in early 2020, following initial reports from the United Kingdom and Italy. Also known as Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS), MIS-C was rapidly recognized as a delayed, potentially life-threatening complication arising after SARS-CoV-2 infection. Unlike acute COVID-19, which is often mild or asymptomatic in children, MIS-C is characterized by a pronounced hyperinflammatory response, with symptoms typically appearing two to five weeks after the initial infection. The syndrome has raised major concern due to its potential for rapid clinical deterioration and severe multi-organ involvement, particularly affecting the cardiovascular system.</div><div>Over the past five years, a growing body of research has substantially advanced our understanding of MIS-C, encompassing its pathophysiological mechanisms, clinical presentation, diagnostic criteria, treatment strategies, and long-term outcomes. In view of the persistent epidemiology of COVID-19, this article synthesizes current knowledge within the framework of a personalized medicine approach, highlights recent insights from advanced peer-reviewed studies, and underscores the need for tailored therapeutic strategies to optimize patient care.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100313"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating clinical pharmacy into pediatric care pathways: Impact on medication safety and multidisciplinary collaboration","authors":"Laura Colonges ,&nbsp;Coralie Reygner ,&nbsp;Jérémy Jost ,&nbsp;Thomas Lauvray ,&nbsp;Christophe Piguet ,&nbsp;Eva de Berranger ,&nbsp;Vincent Guigonis ,&nbsp;Stéphanie Bonnet","doi":"10.1016/j.gpeds.2025.100312","DOIUrl":"10.1016/j.gpeds.2025.100312","url":null,"abstract":"<div><h3>Background</h3><div>The high number of off-label medications and the unique pharmacokinetic characteristics of children make pediatrics a complex specialty with a high risk of medication errors, in which the clinical pharmacist has an important role to play.</div></div><div><h3>Objective</h3><div>To develop clinical pharmacy activities and evaluate their impact in pediatric departments to improve the safety of care for hospitalized children.</div></div><div><h3>Methods and settings</h3><div>We created specific patient pathways and assigned clinical pharmacy activities tailored to their needs (medication reviews, pharmaceutical interviews, etc.). A satisfaction survey was distributed to patients and healthcare professionals to gather feedback on our practices. We also systematized the pharmaceutical analysis of pediatric prescriptions to detect errors early and implemented a daily pharmacist presence in the pediatric hospital. All results were recorded in an Excel® spreadsheet and analyzed.</div></div><div><h3>Results</h3><div>In total, 85.0 % of prescription lines were reviewed (<em>n</em> = 5558), and 56 pharmaceutical interventions were issued (1 per 100 lines reviewed), with an acceptance rate of 94.6 %. Additionally, 98 pharmaceutical consultations were requested. Four months after implementation, four patient pathways were created: oncology/hematology, initiation of chronic treatment (standard or extemporaneously prepared by the hospital) and hospitalization at home. Families rated the service an average of 9.0/10, and 72.4 % of healthcare professionals reported being \"very satisfied\" with the pharmaceutical activities.</div></div><div><h3>Conclusion</h3><div>Just a few months after the introduction of clinical pharmacy activities, the pharmacist is already recognized as an essential member of the team, helping to secure the care pathway of young patients. The next steps include expanding the existing pathways and creating new ones.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"15 ","pages":"Article 100312"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}