细菌感染、生物膜和抗生素敏感性的免疫代谢调节。

IF 4.7 3区 医学 Q2 IMMUNOLOGY Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-02-03 DOI:10.1159/000536649
Ying-Tsun Chen, Gaurav Kumar Lohia, Samantha Chen, Sebastián A Riquelme
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引用次数: 0

摘要

背景:粘膜组织在受到感染时会激活剧烈的炎症反应以清除病原体:即抗病能力。抗病能力是由组织驻留的巨噬细胞协调的,这些巨噬细胞在感知病原体后会进行深刻的新陈代谢重编程。这些代谢激活的巨噬细胞会释放许多炎症因子,从而促进其杀菌功能。然而,在免疫功能健全的个体中,铜绿假单胞菌、金黄色葡萄球菌和沙门氏菌等病原体会逃避这种免疫,生成长期繁衍的群落。此外,抗生素疗法撤消后,"顽固 "细胞会迅速崛起,引发炎症复发,从而恶化宿主健康。这些病原体是如何在充满活化巨噬细胞的炎症组织中持续存在的,目前仍不甚明了:在这篇综述中,我们讨论了最近的研究发现,铜绿假单胞菌、金黄色葡萄球菌和沙门氏菌进化生物膜和抗生素耐受性的能力是由调节巨噬细胞代谢重编程的类似代谢途径促进的。
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Immunometabolic Regulation of Bacterial Infection, Biofilms, and Antibiotic Susceptibility.

Background: Upon infection, mucosal tissues activate a brisk inflammatory response to clear the pathogen, i.e., resistance to disease. Resistance to disease is orchestrated by tissue-resident macrophages, which undergo profound metabolic reprogramming after sensing the pathogen. These metabolically activated macrophages release many inflammatory factors, which promote their bactericidal function. However, in immunocompetent individuals, pathogens like Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella evade this type of immunity, generating communities that thrive for the long term.

Summary: These organisms develop features that render them less susceptible to eradication, such as biofilms and increased tolerance to antibiotics. Furthermore, after antibiotic therapy withdrawal, "persister" cells rapidly upsurge, triggering inflammatory relapses that worsen host health. How these pathogens persisted in inflamed tissues replete with activated macrophages remains poorly understood.

Key messages: In this review, we discuss recent findings indicating that the ability of P. aeruginosa, S. aureus, and Salmonella to evolve biofilms and antibiotic tolerance is promoted by the similar metabolic routes that regulate macrophage metabolic reprogramming.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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