Arexvy:全面回顾呼吸道合胞病毒疫苗带来的革命性保护。

IF 1.5 4区 医学 Q4 IMMUNOLOGY Viral immunology Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI:10.1089/vim.2023.0093
M Swathi
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引用次数: 0

摘要

呼吸道合胞病毒(RSV)是儿童急性下呼吸道感染的主要病因,对老年人也有很大风险。开发 RSV 疫苗一直是当务之急,最近批准的 Arexvy 疫苗在预防 60 岁及以上老年人因 RSV 引起的下呼吸道疾病 (LRTD) 方面显示出了良好的前景。本综述讨论了 RSV 的历史、疫苗开发中的挑战以及 Arexvy 的作用机制。根据 3 期临床试验,探讨了该疫苗的有效性和安全性,证明了它在预防 RSV 相关 LRTD 方面的有效性。最常见的不良反应包括注射部位疼痛、疲劳、肌痛、头痛和关节痛。目前正在进行的研究重点是 Arexvy 的长期有效性,包括是否需要加强剂量及其对减少 RSV 相关住院率的影响。研究强调了Arexvy在减轻RSV相关疾病负担方面的潜力,尤其是在弱势群体中的潜力,并强调了广泛开展免疫接种工作和普及这种突破性疫苗的重要性。
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Arexvy: A Comprehensive Review of the Respiratory Syncytial Virus Vaccine for Revolutionary Protection.

The respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in children and poses a significant risk to older adults. Developing a vaccine against RSV has been a priority, and the recently approved Arexvy vaccine has shown promise in preventing lower respiratory tract disease (LRTD) caused by RSV in individuals aged 60 years and older. This comprehensive review discusses the history of RSV, challenges in vaccine development, and the mechanism of action of Arexvy. The efficacy and safety of the vaccine are explored based on phase 3 clinical trial, demonstrating its effectiveness in preventing RSV-associated LRTD. The most common adverse reactions reported include injection site pain, fatigue, myalgia, headache, and arthralgia. Ongoing research focuses on the long-term effectiveness of Arexvy, including the need for booster doses and its impact on reducing RSV-associated hospitalizations. The potential of Arexvy to lessen the burden of RSV-related illnesses, particularly in vulnerable populations, is highlighted, emphasizing the importance of widespread immunization efforts and accessibility to this groundbreaking vaccine.

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来源期刊
Viral immunology
Viral immunology 医学-病毒学
CiteScore
3.60
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology coverage includes: Human and animal viral immunology Research and development of viral vaccines, including field trials Immunological characterization of viral components Virus-based immunological diseases, including autoimmune syndromes Pathogenic mechanisms Viral diagnostics Tumor and cancer immunology with virus as the primary factor Viral immunology methods.
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