设计超小型铈基金属有机框架纳米酶，用于干眼症的高效抗氧化治疗（Adv.）

IF 19 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Functional Materials Pub Date : 2024-02-05 DOI:10.1002/adfm.202470034

Zhongxing Chen, Zheng Li, Nana Tang, Yida Huang, Siheng Li, Wenjin Xu, Qing Wang, Xin Chen, Nan Zhao, Zhenhai Zeng, Yichen Xiao, Xinyi Chen, Jiawei Li, Xingtao Zhou, Guisheng Li, Mei Yang, Jinhai Huang

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摘要

超小型Ce-MOFs纳米酶ln文章编号：2307569，周兴涛、李桂生、杨梅、黄进海及其合作者开发了超小型铈基金属有机框架（Ce-MOFs）纳米酶，用于干眼病（DED）的高效抗氧化治疗。所获得的超小型 Ce-MOF 3（2 nm）具有卓越的清除 ROS 和抗氧化能力，降低了细胞毒性，并具有良好的眼部渗透性。在治疗方面，Ce-MOF 3 可抑制氧化应激和炎症反应，促进角膜上皮修复，促进泪液分泌恢复，从而有效缓解 DED。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Engineering Ultra-Small Cerium-Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease (Adv. Funct. Mater. 6/2024)

Ultrasmall Ce-MOFs Nanozymes

ln article number 2307569, Xingtao Zhou, Guisheng Li, Mei Yang, Jinhai Huang, and co-workers develop ultra-small cerium-based metal organic frameworks (Ce-MOFs) nanozymes for efficient antioxidative treatment of dry eye disease (DED). The obtained ultra-small Ce-MOF 3 (2 nm) exhibits superior ROS scavenging and antioxidant capacity, decreased cytotoxicity, and excellent ocular penetration. Therapeutically, Ce-MOF 3 is demonstrated to be highly efficient in alleviating DED by suppressing oxidative stress and inflammation, boosting corneal epithelial repair, and facilitating tear secretion recovery.

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.