Rafat M Mohareb, Sayeed Mukhtar, Humaira Parveen, Mahmoud A Abdelaziz, Ensaf S Alwan
{"title":"新型噻吩衍生物的抗增殖、形态和分子对接研究及其在离子液体固定化反应中的策略","authors":"Rafat M Mohareb, Sayeed Mukhtar, Humaira Parveen, Mahmoud A Abdelaziz, Ensaf S Alwan","doi":"10.2174/0118715206262307231122104748","DOIUrl":null,"url":null,"abstract":"<p><p>We regret to inform you that the article titled “Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene Derivatives and their Strategy in Ionic Liquids Immobilized Reactions,” published in Volume 24, Issue 9, 2024 of Anti-Cancer Agents in Medicinal Chemistry (10.2174/0118715206262307231122104748), is being retracted.</p><p><p>After a thorough investigation, it was found that there was potential data manipulation in the spectral data provided in the manuscript. The integrity of the data presented in the study could not be verified, leading to the decision to retract the article</p><p><p>We apologize for any inconvenience this may have caused and appreciate your understanding in this matter.</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":7934,"journal":{"name":"Anti-cancer agents in medicinal chemistry","volume":" ","pages":"691-708"},"PeriodicalIF":2.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retracted: Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene Derivatives and their Strategy in Ionic Liquids Immobilized Reactions\",\"authors\":\"Rafat M Mohareb, Sayeed Mukhtar, Humaira Parveen, Mahmoud A Abdelaziz, Ensaf S Alwan\",\"doi\":\"10.2174/0118715206262307231122104748\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We regret to inform you that the article titled “Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene Derivatives and their Strategy in Ionic Liquids Immobilized Reactions,” published in Volume 24, Issue 9, 2024 of Anti-Cancer Agents in Medicinal Chemistry (10.2174/0118715206262307231122104748), is being retracted.</p><p><p>After a thorough investigation, it was found that there was potential data manipulation in the spectral data provided in the manuscript. The integrity of the data presented in the study could not be verified, leading to the decision to retract the article</p><p><p>We apologize for any inconvenience this may have caused and appreciate your understanding in this matter.</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>\",\"PeriodicalId\":7934,\"journal\":{\"name\":\"Anti-cancer agents in medicinal chemistry\",\"volume\":\" \",\"pages\":\"691-708\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anti-cancer agents in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0118715206262307231122104748\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anti-cancer agents in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0118715206262307231122104748","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
背景:人们对吡喃和噻吩衍生物进行了大量研究,认为这些衍生物具有广泛的生物活性,包括抗浆膜炎,以及作为caspase、丙型肝炎和癌症抑制剂:5-acetyl-2-amino-4-(phenylamino)-thiophene-3-carbonitrile 的多组分反应产生了具有生物活性的目标分子,如吡喃及其融合衍生物。研究了常规催化多组分反应与无溶剂离子液体固定化多组分反应之间的比较:方法:这项工作中的多组分反应不仅在以三乙胺为催化剂的回流条件下进行,而且还在无溶剂离子液体固定化磁性纳米粒子(MNPs)催化剂中进行:通过这项工作,我们合成并鉴定了 31 种新化合物,并对六种癌细胞系(即 A549、HT-29、MKN-45、U87MG、SMMC-7721 和 H460)进行了评估。根据疾病分类,对十七种癌细胞株进一步筛选出了最具活性的化合物。此外,还选择了化合物 11e 对 A549 细胞系的影响,以进一步改变该细胞系的形态。对 11e 和 11f 进行了分子对接研究,结果令人鼓舞:由噻吩衍生物衍生的杂环化合物的合成一直备受关注。经过详细的优化研究发现,无溶剂离子液体固定化多组分合成法可以获得高产率的化合物,为这一与合成相关的转化开辟了更绿色的程序。合成的许多化合物可被视为抗癌剂,从而促进了进一步的研究。
Retracted: Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene Derivatives and their Strategy in Ionic Liquids Immobilized Reactions
We regret to inform you that the article titled “Anti-proliferative, Morphological and Molecular Docking Studies of New Thiophene Derivatives and their Strategy in Ionic Liquids Immobilized Reactions,” published in Volume 24, Issue 9, 2024 of Anti-Cancer Agents in Medicinal Chemistry (10.2174/0118715206262307231122104748), is being retracted.
After a thorough investigation, it was found that there was potential data manipulation in the spectral data provided in the manuscript. The integrity of the data presented in the study could not be verified, leading to the decision to retract the article
We apologize for any inconvenience this may have caused and appreciate your understanding in this matter.
Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
期刊介绍:
Formerly: Current Medicinal Chemistry - Anti-Cancer Agents.
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.
Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.