Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Alberto Marcos Bermejo , César Venero , Salem Amara , Ahmed Landoulsi
{"title":"谷氨酸修饰的二氧化硅纳米粒子在促进大脑健康方面的作用","authors":"Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Alberto Marcos Bermejo , César Venero , Salem Amara , Ahmed Landoulsi","doi":"10.1016/j.arres.2024.100095","DOIUrl":null,"url":null,"abstract":"<div><p>SiO<sub>2</sub> nanoparticles functionalized with glutamate were investigated for their ability to alleviate oxidative stress caused by prolonged exposure to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). The study involved ten different groups, each consisting of eight animals, to examine the effects of H<sub>2</sub>O<sub>2</sub> <strong>-</strong>induced oxidative stress. The results demonstrated that exposure to H<sub>2</sub>O<sub>2</sub> stress oxidative biomarkers were altered accompanied with a loss of spatial learning and memory in rats performing the Morris water maze task. Furthermore, SiO<sub>2</sub> nanoparticles functionalized with L-glutamic acid alleviated the H<sub>2</sub>O<sub>2</sub>-induced acceleration of necrotic and degenerative cell changes in the hippocampus, subiculum, caudate-putamen, and frontal cortex. Additionally, L-glutamic acid-functionalized SiO<sub>2</sub> nanoparticles reduced the redox imbalance and interfered with acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities induced by H<sub>2</sub>O<sub>2</sub>.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100095"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266713792400002X/pdfft?md5=d8351624bade960149df60700963867b&pid=1-s2.0-S266713792400002X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The role of glutamic acid-modified silica nanoparticles in promoting brain health\",\"authors\":\"Essia Hamdi , Slah Hidouri , Ana-Belén Muniz-Gonzalez , Alberto Marcos Bermejo , César Venero , Salem Amara , Ahmed Landoulsi\",\"doi\":\"10.1016/j.arres.2024.100095\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>SiO<sub>2</sub> nanoparticles functionalized with glutamate were investigated for their ability to alleviate oxidative stress caused by prolonged exposure to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). The study involved ten different groups, each consisting of eight animals, to examine the effects of H<sub>2</sub>O<sub>2</sub> <strong>-</strong>induced oxidative stress. The results demonstrated that exposure to H<sub>2</sub>O<sub>2</sub> stress oxidative biomarkers were altered accompanied with a loss of spatial learning and memory in rats performing the Morris water maze task. Furthermore, SiO<sub>2</sub> nanoparticles functionalized with L-glutamic acid alleviated the H<sub>2</sub>O<sub>2</sub>-induced acceleration of necrotic and degenerative cell changes in the hippocampus, subiculum, caudate-putamen, and frontal cortex. Additionally, L-glutamic acid-functionalized SiO<sub>2</sub> nanoparticles reduced the redox imbalance and interfered with acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities induced by H<sub>2</sub>O<sub>2</sub>.</p></div>\",\"PeriodicalId\":72106,\"journal\":{\"name\":\"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe\",\"volume\":\"10 \",\"pages\":\"Article 100095\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S266713792400002X/pdfft?md5=d8351624bade960149df60700963867b&pid=1-s2.0-S266713792400002X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S266713792400002X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266713792400002X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The role of glutamic acid-modified silica nanoparticles in promoting brain health
SiO2 nanoparticles functionalized with glutamate were investigated for their ability to alleviate oxidative stress caused by prolonged exposure to hydrogen peroxide (H2O2). The study involved ten different groups, each consisting of eight animals, to examine the effects of H2O2-induced oxidative stress. The results demonstrated that exposure to H2O2 stress oxidative biomarkers were altered accompanied with a loss of spatial learning and memory in rats performing the Morris water maze task. Furthermore, SiO2 nanoparticles functionalized with L-glutamic acid alleviated the H2O2-induced acceleration of necrotic and degenerative cell changes in the hippocampus, subiculum, caudate-putamen, and frontal cortex. Additionally, L-glutamic acid-functionalized SiO2 nanoparticles reduced the redox imbalance and interfered with acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities induced by H2O2.
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