Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe最新文献

{"title":"Evaluation of salivary total antioxidant capacity in cigarette smokers versus water pipe smokers among dental students in Sulaimani city","authors":"Darya Khalid Mahmood","doi":"10.1016/j.arres.2026.100154","DOIUrl":"10.1016/j.arres.2026.100154","url":null,"abstract":"<div><h3>Background</h3><div>Tobacco use, whether through cigarettes or waterpipes, has been associated with the development of oxidative stress and a reduction in antioxidant defense. There is dearth of information on the impact of smoking frequency and duration among individuals of close age brackets. This study therefore aimed to assess salivary Total Antioxidant Capacity (TAOc) concentration among male dental students of different narrow age range with different smoking habits, including non-smokers, cigarette smokers, waterpipe users, and dual users.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 89 male dental students aged approximately 21.3 years were divided into four groups: non-smokers (n=14), cigarette smokers (<em>n</em> = 39), waterpipe users (n=11), and dual users (n=25). Smoking frequency and duration were recorded, and TAOc levels were measured. Data were analyzed using one-way ANOVA and post hoc Tukey tests.</div></div><div><h3>Results</h3><div>A significant difference in TAOc levels was observed among the four groups (<em>P</em> &lt; 0.05). Non-smokers exhibited the highest antioxidant levels (27.93±3.79 U/ml), followed by waterpipe smokers (17.40±6.02 U/ml), cigarette smokers (15.59±7.45 U/ml), and dual users (9.68±6.89 U/ml). Post hoc analysis revealed that non-smokers had significantly higher TAOc levels compared to all smoking groups (<em>P</em> ≤ 0.001). Additionally, dual users had significantly lower TAOc than both single-type smokers. Smoking duration and frequency also influenced antioxidant levels, with a significant reduction observed in those with longer durations of use or higher frequency of smoking consumption.</div></div><div><h3>Conclusion</h3><div>Smoking, particularly dual use of cigarettes and waterpipes, is associated with a significant decline in salivary antioxidant capacity. Longer smoking duration and higher frequency further exacerbate this decline, highlighting the potential oxidative damage associated with tobacco use in young adults.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100154"},"PeriodicalIF":2.7,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of pteridines and statins on cancer: A therapeutic strategy targeting nitric oxide synthase (NOS) pathway","authors":"Jerimon Johnson ,&nbsp;Monisha Krishnan ,&nbsp;Sasireka Manikandan ,&nbsp;Nivetha Shanmuganathan ,&nbsp;Martinahingis Kennedy ,&nbsp;Kris Santhiya Yeasuraj ,&nbsp;Sridhar Muthusami ,&nbsp;Angayarkanni Jayaraman","doi":"10.1016/j.arres.2026.100152","DOIUrl":"10.1016/j.arres.2026.100152","url":null,"abstract":"<div><div>A family of enzymes known as nitric oxide synthases (NOS) produces nitric oxide (NO), a tiny, unstable, and potentially hazardous gas that is highly diffusible across cell membranes. NO and NO metabolites, such as nitrite, nitrate, S-nitrosothiols, nitrosamines, and peroxynitrite, mediate a variety of cytotoxic and genotoxic effects, such as inhibition of mitochondrial respiration, protein and DNA damage that leads to gene mutation, loss of protein function, necrosis, and apoptosis. Through a variety of apoptotic mechanisms, abnormally elevated NO generation by NOS II/iNOS may cause cytotoxicity of cancer cells. Tetrahydrobiopterin (BH4) is required by all NOS isoforms for NO production. Another way mammalian cells can create BH4 is by the \"salvage pathway,\" which uses sepiapterin reductase and dihydrofolate reductase to convert sepiapterin to BH4. Better apoptotic effects on cancer cells may result from boosting BH4 levels by treating cells with sepiapterin, 7-8-dihydropterin, or pterin derivatives, which work in concert to improve NO levels. Another common medication used to treat and prevent hypercholesterolaemia and related cardiovascular disorders is statins, which lower serum cholesterol. They are competitive inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, the enzyme that limits the rate at which cholesterol is produced. Statins also improve cardiovascular and endothelial function by increasing the generation of nitric oxide (NO) by endothelial cells. They also have an impact on a variety of molecules and signaling pathways that govern the synthesis of apoptotic proteins and raise nitric oxide (NO) levels. Therefore, the NO-mediated route may be used to induce apoptosis due to the synergistic potency of statins and pterin derivatives. This review focusses on the effectiveness of statins and pterin derivatives, as well as their ability to influence the production of nitric oxide, which intensifies the effect on cancer cells.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100152"},"PeriodicalIF":2.7,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the AGE-RAGE axis in acute lung injury: Mechanistic insights and redox-modulatory strategies","authors":"Changchang Zhang ,&nbsp;Xiao Yu ,&nbsp;Peiji Li ,&nbsp;Xiangmei Li ,&nbsp;Jingwen Chen ,&nbsp;Huan Wang ,&nbsp;Mengying Yao","doi":"10.1016/j.arres.2026.100151","DOIUrl":"10.1016/j.arres.2026.100151","url":null,"abstract":"<div><div>Acute Respiratory Distress Syndrome (ARDS) is a serious respiratory condition characterized by a rapid onset of severe inflammation in the lungs. This inflammation results from various causes. The syndrome is marked by widespread damage to the alveolar epithelial cells and capillary endothelial cells. It represents a critical stage of acute lung injury (ALI), a prevalent clinical issue associated with a high mortality rate. The underlying mechanisms of ALI are intricate and primarily driven by an uncontrolled inflammatory response. Given this complexity, there has been growing interest recently in the role of advanced glycation end-products (AGEs) and their receptor, the receptor for advanced glycation end-products (RAGE), in the development of ALI. The AGE-RAGE signaling pathway is pivotal in the initiation and progression of ALI, influencing several processes, including inflammation and apoptosis. However, the detailed mechanisms by which this signaling pathway contributes to ALI are still being investigated. This review aims to summarize recent advancements in understanding the molecular mechanisms, regulation of inflammatory responses, and apoptosis associated with the AGE-RAGE signaling pathway in ALI. It focuses on analyzing how various traditional Chinese medicine formulas and their active components can modulate this pathway to alleviate ALI. Additionally, by integrating network pharmacology, molecular docking, and experimental validation, this review examines the interactions between the AGE-RAGE signaling pathway and significant downstream pathways such as NF-κB and PI3K/AKT, highlighting their potential therapeutic implications. Therefore, this work provides a foundational understanding of the pathogenesis of ALI and paves the way for the development of innovative therapeutic approaches.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100151"},"PeriodicalIF":2.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of atorvastatin on inflammatory markers, lipid profile, and renal function in kidney diseases: a systematic review and meta-analysis of randomized controlled trials","authors":"Iman Mohammadi ,&nbsp;Behzad Einollahi ,&nbsp;Mina Alimohammadi ,&nbsp;Seyedeh Mahdieh Khoshnazar ,&nbsp;Hoda Sadeghi ,&nbsp;Ali Zahiri ,&nbsp;Haniye Najafzadeh ,&nbsp;Kiavash Hushmandi","doi":"10.1016/j.arres.2026.100150","DOIUrl":"10.1016/j.arres.2026.100150","url":null,"abstract":"<div><h3>Background</h3><div>Chronic and acute kidney disorders (CKD, AKI) afflict millions globally, leading to increased morbidity and death, especially from cardiovascular consequences. Atorvastatin, a popular statin, offers lipid-lowering, anti-inflammatory, and antioxidant qualities that may assist kidney disease patients in terms of renal and cardiovascular health. This meta-analysis assesses atorvastatin's effectiveness and safety in terms of lipid profiles, inflammatory biomarkers, and renal function in patients with kidney disorders.</div></div><div><h3>Methods</h3><div>A thorough search of Scopus, Cochrane, Embase, Web of Science, Google Scholar, and PubMed until January 2025 revealed randomized controlled trials (RCTs) evaluating atorvastatin in CKD, diabetic nephropathy, hemodialysis, and other renal diseases. The outcomes included lipid parameters (HDL, LDL, total cholesterol, triglycerides), inflammatory markers (hsCRP, IL-6, MDA), and renal function indices. Random-effects models were used to pool weighted mean differences (WMDs) and 95 % confidence intervals (CIs). Subgroup analyses were performed based on dosage, duration, disease type, and treatment type. The risk of bias and publication bias was evaluated.</div></div><div><h3>Results</h3><div>Twelve RCTs with 18 trials and sample sizes ranging from 21 to 156 participants were included. As expected, atorvastatin significantly improved HDL cholesterol (WMD: 2.74 mg/dL; 95 % CI: 0.57 to 4.91; <em>p</em> &lt; 0.001) while dramatically decreasing LDL cholesterol (WMD: -13.09 mg/dL; 95 % CI: -21.17 to -5.00; <em>p</em> &lt; 0.001) and total cholesterol (WMD: -15.28 mg/dL; 95 % CI: -24.58 to -5.98; <em>p</em> &lt; 0.001) at lower dosages of ≤10 mg/day and longer treatment periods. More notably, it also reduced MDA (WMD: -2.80; 95 % CI: -3.62 to -1.97; <em>p</em> &lt; 0.001) and showed anti-inflammatory effects by reducing hsCRP in CKD patients receiving <em>a</em> ≤ 10 mg/day dosage.</div></div><div><h3>Conclusions</h3><div>Atorvastatin medication improves lipid profiles and lowers oxidative stress indicators in renal disease patients, with some indications of decreased inflammation in select subgroups, indicating a possible function as an adjuvant treatment to reduce cardiovascular risk. Future large-scale RCTs are needed to determine the appropriate dose and long-term kidney results.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100150"},"PeriodicalIF":2.7,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of L-carnitine in exercise training: Anti-inflammatory, antioxidant, and metabolic interactions","authors":"Soheil Aminizadeh ,&nbsp;Aliasghar Zarezadehmehrizi ,&nbsp;Maedeh Amiri Deh-Ahmadi ,&nbsp;Beydolah Shahouzehi","doi":"10.1016/j.arres.2025.100149","DOIUrl":"10.1016/j.arres.2025.100149","url":null,"abstract":"<div><div>L-carnitine is a mitochondria-targeted compound that plays a pivotal role in lipid metabolism, redox balance, and inflammatory regulation, particularly under conditions of elevated metabolic demands such as exercise. This review explores the multifaceted functions of L-carnitine in modulating oxidative stress and inflammation, emphasizing its relevance to exercise physiology and clinical health. By facilitating the transport of long-chain fatty acids into mitochondria, L-carnitine enhances β-oxidation and energy production while buffering excess acetyl-CoA to maintain metabolic flexibility. Its antioxidant properties, mediated through the upregulation of SOD, GPx, and catalase, help mitigate reactive oxygen species (ROS) and preserve mitochondrial integrity. Concurrently, L-carnitine suppresses cytokines such as TNF-α and IL-6, interrupting the feedback loop between oxidative stress and chronic inflammation. These mechanisms are particularly beneficial during and after exercise, where L-carnitine supplementation has shown potential to improve endurance, reduce muscle damage, and accelerate recovery in some studies, although findings across the literature are not entirely consistent. Clinical evidence also supports its therapeutic potential in conditions like cardiovascular disease, non-alcoholic fatty liver disease, and neuroinflammation. The review integrates mechanistic insights with performance outcomes, highlighting L-carnitine’s role as both a metabolic modulator and an ergogenic aid. Understanding these complex interactions provides a foundation for optimizing L-carnitine use, yet further research is warranted to clarify the optimal form (e.g., LCLT, ALCAR), dosage, duration, and target populations to maximize its therapeutic and ergogenic potential.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100149"},"PeriodicalIF":2.7,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A concise review on health benefits of alkaline reduced water","authors":"Maninder Meenu ,&nbsp;Mradula ,&nbsp;Kiran Khandare ,&nbsp;Shradha Duggal ,&nbsp;Vasudha Bansal ,&nbsp;Manorma Negi ,&nbsp;Baojun Xu","doi":"10.1016/j.arres.2025.100148","DOIUrl":"10.1016/j.arres.2025.100148","url":null,"abstract":"<div><div>Alkaline reduced water (ARW), produced through electrolysis, has emerged as a health-promoting beverage due to its elevated pH and reduced oxidation–reduction potential (ORP). This type of water offers several notable health benefits. ARW effectively neutralizes excess body acidity, promoting a balanced internal pH, which is beneficial in counteracting the effects of an acid-heavy diet. Its smaller molecular clusters enhance cellular absorption, improving hydration and nutrient uptake, which is particularly advantageous for athletes and physically active individuals. The antioxidant properties of ARW, attributed to its negative ORP, play a crucial role in reducing oxidative stress, thereby protecting cells from damage and potentially lowering the risk of chronic diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. ARW also supports digestive health by promoting a balanced gut environment and reducing harmful bacterial load. It also enhances the solubility and bioavailability of nutrients, improving their utilization in the body. Regular consumption of ARW has been linked to a lower incidence of chronic diseases and reduced fatigue, further enhancing energy levels. Overall ARW is a valuable addition to a health-conscious lifestyle, offering comprehensive benefits by enhancing hydration and preventing diseases. However, further research is needed to fully elucidate the long-term effects of ARW.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100148"},"PeriodicalIF":2.7,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EROS protein: Decoding its pivotal role in redox homeostasis and disease pathogenesis","authors":"Shiyu Liang ,&nbsp;Youli Zhou ,&nbsp;Wenfeng Ren ,&nbsp;Yang Xu ,&nbsp;Ming Tang ,&nbsp;Yuxi Su ,&nbsp;Li Li ,&nbsp;Mei Gao","doi":"10.1016/j.arres.2025.100147","DOIUrl":"10.1016/j.arres.2025.100147","url":null,"abstract":"<div><div>The Essential for Reactive Oxygen Species (EROS) protein, a critical molecular chaperone for NADPH oxidase 2 (NOX2/gp91^phox), has emerged as a central regulator of redox signaling and immune defense. Recent structural and functional studies reveal that EROS orchestrates NOX2 maturation, prevents spontaneous activation, and regulates reactive oxygen species (ROS) production. Dysfunction of EROS is implicated in chronic granulomatous disease (CGD), cancers and vascular pathologies. This review integrates structural insights into EROS-NOX2 interactions, discusses its dual roles in maintaining redox equilibrium and triggering oxidative stress, and explores therapeutic strategies targeting EROS-dependent pathways.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100147"},"PeriodicalIF":2.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145738770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylglyoxal in cancer: Bidirectional regulatory networks and precision intervention—From metabolic reprogramming to cross-disease synergistic targeting","authors":"Ji ZeZhao","doi":"10.1016/j.arres.2025.100146","DOIUrl":"10.1016/j.arres.2025.100146","url":null,"abstract":"<div><div>Methylglyoxal (MG), a core byproduct of glycolysis, exerts a dual role in cancer via a \"dose-dependent hormesis effect\". At low concentrations, it promotes tumor proliferation and metastasis by regulating polyamine metabolism, epigenetic modifications, and the immune microenvironment. In contrast, high concentrations of MG trigger tumor cell apoptosis through inducing DNA damage and protein glycation. Unlike traditional reviews that focus solely on \"MG toxicity\" or \"GLO1 as a single target\", this review takes \"metabolic network-signal crosstalk-cross-disease association\" as the core context. It systematically dissects the bidirectional regulatory mechanisms of MG in cancer, highlights emerging pathways such as non-coding RNA-mediated GLO1 regulation, MG-polyamine metabolism crosstalk, and immunometabolic reprogramming, and integrates the MG regulatory network in cross-disease scenarios including diabetes, HIV infection, and occupational exposure. Finally, a \"stratified targeting + synergistic intervention\" precision therapeutic strategy is proposed, providing a novel perspective for basic research and clinical translation of MG-related cancers.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"18 ","pages":"Article 100146"},"PeriodicalIF":2.7,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ozone therapy on oxidative stress indices in chronic inflammatory diseases: A systematic review and meta-analysis of randomized clinical trials","authors":"Mina Alimohammadi ,&nbsp;Seyedeh Mahdieh Khoshnazar ,&nbsp;Hamid Khajehpour ,&nbsp;Morteza Izadi ,&nbsp;Behzad Einollahi ,&nbsp;Kiavash Hushmandi","doi":"10.1016/j.arres.2025.100143","DOIUrl":"10.1016/j.arres.2025.100143","url":null,"abstract":"<div><h3>Background</h3><div>Chronic inflammatory diseases (CIDs) are defined by prolonged inflammation and oxidative stress (OS), both of which are associated with disease progression and consequences. Ozone (O₃) therapy is recognized as a promising complementary therapy for regulating OS indicators. The purpose of this systematic review and meta-analysis is to investigate the effect of O₃ therapy on OS parameters in patients with CID.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across multiple databases, including PubMed, Cochrane Library, Google Scholar, and Scopus, for randomized controlled trials (RCTs) published up to October 2024. Studies were selected if they investigated the effect of ozone therapy on OS parameters, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), total hydroperoxides (TH), advanced oxidation protein products (AOPP), and protein peroxidation (PP) in CID patients. Fixed- or Random-effects models were used in the meta-analysis to determine weighted mean differences (WMD) and 95 % confidence intervals (CIs).</div></div><div><h3>Results</h3><div>12 RCTs with 846 participants included in the current study. Our findings showed that O₃ therapy had no significant difference in OS parameters when compared to control groups. According to subgroup analysis, O₃ therapy significantly increased SOD activity in patients with T2D (WMD = 7.59, 95 % CI [2.98 to 12.19], I² = 97.75 %, <em>p</em> = &lt;0.001) and arthritis (WMD = 9.21, 95 % CI [6.02 to 12.40], I² = 66.96 %, <em>p</em> = 0.08). In addition, the rectal method showed a statistically significant effect on GPx activity (WMD = 20.00, 95 % CI [0.55 to 39.45], I² = 92.42 %, <em>p</em> = &lt;0.001). O₃ therapy also significantly reduced AOPP levels at doses of ≥20 µg/ml and treatment durations of both &lt;30 days (WMD = −5.15, 95 % CI [−7.90 to −2.40], I² = 96.03 %, <em>p</em> = &lt;0.001).</div></div><div><h3>Conclusion</h3><div>Ozone therapy could improve OS markers in individuals with CIDs, mostly by lowering AOPP and strengthening antioxidant defense systems. More large-scale RCTs are required to validate these outcomes and better comprehend the fundamental mechanisms of action.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"17 ","pages":"Article 100143"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary metal chelator, phytochelatin 2, increases selenium and alters metal homeostasis and associated lipid metabolism in the liver","authors":"Zachery R. Jarrell,&nbsp;Ho Young Lee,&nbsp;Choon-Myung Lee,&nbsp;Michael L. Orr,&nbsp;Dean P. Jones,&nbsp;Young-Mi Go","doi":"10.1016/j.arres.2025.100144","DOIUrl":"10.1016/j.arres.2025.100144","url":null,"abstract":"<div><div>Biological systems have evolved highly regulated systems to ensure homeostatic levels of trace minerals, such as selenium (Se), which are important to metabolic function and signaling. Much of the understanding of these systems is limited to endogenous proteins and small molecules used for trafficking of minerals. Phytochelatins, a class of plant-derived metal chelating peptides with the general structure, (γ-Glu-Cys)_n-Gly, are ubiquitous in the diet and were recently found associated with Se and other metals in human urine. These findings suggest that diet-derived phytochelatins could influence metal homeostasis alongside known endogenous metal-binding compounds. In the present study, we investigated the impact of long-term, oral phytochelatin supplementation on metal homeostasis in a murine model. Phytochelatin supplementation increased Se, zinc and cobalt in the liver and increased urinary Se. Integrative analysis of liver metal profiles with untargeted, high-resolution liver metabolomics revealed dynamic metallome interaction with lipid and carbohydrate metabolism. These results highlight an active role of dietary phytochelatins in modulating mammalian metal homeostasis and associated metabolism. Such dietary components could play a pivotal role in regulating trace metal homeostasis and metal-driven pathophysiology.</div></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"17 ","pages":"Article 100144"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}