微生物代谢物与宿主免疫之间的交叉对话:与过敏性疾病的相关性

IF 4.6 2区 医学 Q2 ALLERGY Clinical and Translational Allergy Pub Date : 2024-02-11 DOI:10.1002/clt2.12339
Purevsuren Losol, Magdalena Wolska, Tomasz P. Wypych, Lu Yao, Liam O'Mahony, Milena Sokolowska
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引用次数: 0

摘要

背景:近几十年来,包括呼吸道和食物过敏在内的过敏性疾病以及过敏性皮肤病的发病率急剧上升。在过敏性疾病中,肠道微生物组存在菌群失调,有益菌的多样性减少,潜在病原体的数量增加。研究结果表明,微生物组受环境和饮食因素的影响很大,在过敏性疾病的发生、发展和严重程度中起着核心作用。微生物组产生的代谢产物可以调节宿主的许多细胞代谢过程和宿主的免疫反应:我们的目标是对微生物代谢物在体内平衡和过敏性疾病中调节宿主免疫功能和免疫代谢的机制进行叙述性和全面的文献综述:我们描述了主要的微生物代谢物,如短链脂肪酸、氨基酸、胆汁酸和多胺,阐明了它们的作用机制、细胞靶点及其在调节先天性和适应性免疫细胞代谢中的作用。此外,我们还描述了细菌代谢物在过敏性疾病(包括过敏性哮喘、特应性皮炎和食物过敏)发病机制中的作用:结论:未来的研究工作应侧重于研究微生物群衍生代谢物的生理功能,以帮助开发新的过敏性疾病诊断和治疗干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases

Background

Allergic diseases, including respiratory and food allergies, as well as allergic skin conditions have surged in prevalence in recent decades. In allergic diseases, the gut microbiome is dysbiotic, with reduced diversity of beneficial bacteria and increased abundance of potential pathogens. Research findings suggest that the microbiome, which is highly influenced by environmental and dietary factors, plays a central role in the development, progression, and severity of allergic diseases. The microbiome generates metabolites, which can regulate many of the host’s cellular metabolic processes and host immune responses.

Aims and Methods

Our goal is to provide a narrative and comprehensive literature review of the mechanisms through which microbial metabolites regulate host immune function and immune metabolism both in homeostasis and in the context of allergic diseases.

Results and Discussion

We describe key microbial metabolites such as short-chain fatty acids, amino acids, bile acids and polyamines, elucidating their mechanisms of action, cellular targets and their roles in regulating metabolism within innate and adaptive immune cells. Furthermore, we characterize the role of bacterial metabolites in the pathogenesis of allergic diseases including allergic asthma, atopic dermatitis and food allergy.

Conclusion

Future research efforts should focus on investigating the physiological functions of microbiota-derived metabolites to help develop new diagnostic and therapeutic interventions for allergic diseases.

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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
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