雄性人耳廓中表达 Spexin 和 nesfatin-1 的神经元。

IF 2.7 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of chemical neuroanatomy Pub Date : 2024-02-09 DOI:10.1016/j.jchemneu.2024.102400
Artur Pałasz , Anna Lipiec-Borowicz , Aleksandra Suszka-Świtek , Julia Kistowska , Petra Horká , Andrzej Kaśkosz , Aneta Piwowarczyk-Nowak , John J. Worthington , Kinga Mordecka-Chamera
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引用次数: 0

摘要

神经肽参与多种脑部活动,负责多种高级精神功能。这项简明、结构性和定性研究的目的是绘制新型调节肽--spexin(SPX)和nesfatin-1在人体鼓室内可能存在的免疫活性图。SPX是一种新发现的多肽,是加兰宁受体(GALR)2/3的天然配体,其分子结构与目前已知的调节因子没有相似之处。SPX 似乎具有多种生理功能,最近在动物实验中发现它参与生殖和食物摄取调节。Nesfatin-1是第二种多效神经肽,它是核宾蛋白-2(NUCB-2)的衍生物,在大脑中分布广泛。Nesfatin-1 是一种具有强烈厌食作用的物质,在调节食物摄入和能量平衡的下丘脑神经元回路中发挥着重要作用。另一方面,nesfatin-1 可能参与多种重要的大脑功能,如睡眠、生殖行为、认知过程、应激反应和焦虑。我们首次使用免疫组化和荧光方法检测并描述了人耳廓中表达内司蛋白-1和SPX的神经元群。这项研究新颖地发现了人耳蜗中 SPX 和 nesfatin-1 免疫阳性神经元,它们的集合体在整个结构中显示出相似的分布模式。
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Spexin and nesfatin-1-expressing neurons in the male human claustrum

Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel regulatory peptides: spexin (SPX) and nesfatin-1 within the human claustrum. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. Nesfatin-1, a second pleiotropic neuropeptide, which is a derivative of the nucleobindin-2 (NUCB-2) protein, is characterized by a wide distribution in the brain. Nesfatin-1 is a substance with a strong anorexigenic effect, playing an important role in the neuronal circuits of the hypothalamus that regulate food intake and energy homeostasis. On the other hand, nesfatin-1 may be involved in several important brain functions such as sleep, reproductive behaviour, cognitive processes, stress responses and anxiety. For the first time we detected and described a population of nesfatin-1 and SPX expressing neurons in the human claustrum using immunohistochemical and fluorescent methods. The study presents the novel identification of SPX and nesfatin-1 immunopositive neurons in the human claustrum and their assemblies show similar patterns of distribution in the whole structure.

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来源期刊
Journal of chemical neuroanatomy
Journal of chemical neuroanatomy 医学-神经科学
CiteScore
4.50
自引率
3.60%
发文量
87
审稿时长
62 days
期刊介绍: The Journal of Chemical Neuroanatomy publishes scientific reports relating the functional and biochemical aspects of the nervous system with its microanatomical organization. The scope of the journal concentrates on reports which combine microanatomical, biochemical, pharmacological and behavioural approaches. Papers should offer original data correlating the morphology of the nervous system (the brain and spinal cord in particular) with its biochemistry. The Journal of Chemical Neuroanatomy is particularly interested in publishing important studies performed with up-to-date methodology utilizing sensitive chemical microassays, hybridoma technology, immunocytochemistry, in situ hybridization and receptor radioautography, to name a few examples. The Journal of Chemical Neuroanatomy is the natural vehicle for integrated studies utilizing these approaches. The articles will be selected by the editorial board and invited reviewers on the basis of their excellence and potential contribution to this field of neurosciences. Both in vivo and in vitro integrated studies in chemical neuroanatomy are appropriate subjects of interest to the journal. These studies should relate only to vertebrate species with particular emphasis on the mammalian and primate nervous systems.
期刊最新文献
Editorial Board Retraction notice to “Astrocyte response to melatonin treatment in rats under high-carbohydrate high-fat diet” [J. Chem. Neuroanat. 136 (2024) 102389] Retraction notice to “Coenzyme Q10 attenuates neurodegeneration in the cerebellum induced by chronic exposure to tramadol” [J. Chem. Neuroanat. 135 (2024) 102367] Retraction notice to “Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus” [J. Chem. Neuroanat. 114(2021) 101946] Retraction notice to “Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats” [J. Chem. Neuroanat. 135 (2024) 102365]
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