{"title":"头颈部细胞病理学：头颈部 FNA 标本中的高危 HPV 检测选择，简明综述","authors":"Tieying Hou, Hector Mesa, Shaoxiong Chen, Mohamed Hamdi Fouad Bikhet, Omer Saeed, Sheila Segura, Harvey Cramer","doi":"10.1016/j.hpr.2024.300731","DOIUrl":null,"url":null,"abstract":"<div><p>High-risk human papillomavirus (HR-HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a unique form of head and neck cancer with distinct biology and better prognosis than conventional SCC. Many patients with HR-HPV positive OPSCC initially present with metastases to lateral neck lymph nodes in levels II or III. Fine-needle aspiration (FNA) is routinely used to establish a diagnosis and evaluate HPV status at these sites. However, there is no consensus regarding the best testing methods for establishing HPV status in cytology specimens. The most common methods include p16 immunohistochemistry, HR-HPV in situ hybridization and molecular tests. This review summarizes the advantages and limitation of each method.</p></div>","PeriodicalId":100612,"journal":{"name":"Human Pathology Reports","volume":"35 ","pages":"Article 300731"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772736X24000033/pdfft?md5=dcd6565c75ba74bf908910f5620c8117&pid=1-s2.0-S2772736X24000033-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Head and neck Cytopathology: Options for high-risk HPV testing in head and neck FNA specimens, a concise review\",\"authors\":\"Tieying Hou, Hector Mesa, Shaoxiong Chen, Mohamed Hamdi Fouad Bikhet, Omer Saeed, Sheila Segura, Harvey Cramer\",\"doi\":\"10.1016/j.hpr.2024.300731\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>High-risk human papillomavirus (HR-HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a unique form of head and neck cancer with distinct biology and better prognosis than conventional SCC. Many patients with HR-HPV positive OPSCC initially present with metastases to lateral neck lymph nodes in levels II or III. Fine-needle aspiration (FNA) is routinely used to establish a diagnosis and evaluate HPV status at these sites. However, there is no consensus regarding the best testing methods for establishing HPV status in cytology specimens. The most common methods include p16 immunohistochemistry, HR-HPV in situ hybridization and molecular tests. This review summarizes the advantages and limitation of each method.</p></div>\",\"PeriodicalId\":100612,\"journal\":{\"name\":\"Human Pathology Reports\",\"volume\":\"35 \",\"pages\":\"Article 300731\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772736X24000033/pdfft?md5=dcd6565c75ba74bf908910f5620c8117&pid=1-s2.0-S2772736X24000033-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Pathology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772736X24000033\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Pathology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772736X24000033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
高危人乳头瘤病毒（HR-HPV）相关口咽鳞状细胞癌（OPSCC）是一种独特的头颈部癌症，具有独特的生物学特性，预后优于传统的SCC。许多 HR-HPV 阳性的口咽鳞状细胞癌患者最初会出现颈侧淋巴结 II 或 III 级转移。细针穿刺术（FNA）是确定诊断和评估这些部位 HPV 状态的常规方法。然而，关于确定细胞学标本中 HPV 状态的最佳检测方法，目前尚未达成共识。最常见的方法包括 p16 免疫组化、HR-HPV 原位杂交和分子检测。本综述总结了每种方法的优点和局限性。
Head and neck Cytopathology: Options for high-risk HPV testing in head and neck FNA specimens, a concise review
High-risk human papillomavirus (HR-HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a unique form of head and neck cancer with distinct biology and better prognosis than conventional SCC. Many patients with HR-HPV positive OPSCC initially present with metastases to lateral neck lymph nodes in levels II or III. Fine-needle aspiration (FNA) is routinely used to establish a diagnosis and evaluate HPV status at these sites. However, there is no consensus regarding the best testing methods for establishing HPV status in cytology specimens. The most common methods include p16 immunohistochemistry, HR-HPV in situ hybridization and molecular tests. This review summarizes the advantages and limitation of each method.
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