COVID-19 与脊髓损伤:住院患者的临床表现、临床过程和临床结果。

IF 0.7 Q4 CLINICAL NEUROLOGY Spinal Cord Series and Cases Pub Date : 2024-02-13 DOI:10.1038/s41394-024-00617-6
Inge E Eriks-Hoogland, Michael A Barth, Lorena L Müller, Dominique Braun, Armin Curt, Mohit Arora, James W Middleton, Jürgen Pannek
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引用次数: 0

摘要

研究设计:回顾性研究 目的:描述脊髓损伤(SCI)住院患者和无症状 COVID-19 感染者的症状/体征、临床过程和预后:描述脊髓损伤(SCI)和无症状 COVID-19 感染住院患者的症状/体征、临床过程和预后:方法: 对症状/体征进行描述性分析:方法:对有症状的 COVID-19 感染和需要住院治疗的 SCI 患者的症状/体征、临床过程和结果进行描述性分析:共纳入 22 名 SCI 患者,其中 15 人(68%)为男性,中位年龄为 64.5 岁(四分位数间距,IQR,52-73 岁)。9人(41%)四肢瘫痪,8人(36%)运动功能完全丧失。常见的临床症状为发热(59%)、咳嗽(54%)、乏力(50%)和呼吸困难(27%)。最常见的并发症是细菌性肺部超级感染(18%)和急性呼吸窘迫综合征(18%)。有 15 人(68%)在住院期间需要接受氧疗,7 人(32%)接受了通气治疗。中位住院时间(LOS)为 23 天(IQR 15-35),因年龄而异,60 岁以下的中位住院时间为 9 天(IQR 8-27),60 岁以上的中位住院时间为 34 天(IQR 17-39)。共有3人(14%)在住院期间死亡,均为老年截瘫患者:结论:并非所有患者都会出现发烧和咳嗽等典型症状。与截瘫患者相比,四肢瘫痪患者的治疗效果并不差,相反,他们的住院时间更短,通气需求也没有差异,死亡率也不高。老年人的住院时间更长。本研究建议对 SCI 患者进行密切监护,以发现 COVID-19 感染的早期症状和体征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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COVID-19 and spinal cord injury: clinical presentation, clinical course, and clinical outcomes of people hospitalised.

Study design: Retrospective study OBJECTIVES: To describe the presenting symptoms/signs, clinical course and outcomes in hospitalised people with spinal cord injury (SCI) and symptomatic COVID-19 infections.

Setting: One university hospital and two SCI centres in Switzerland.

Methods: Descriptive analysis of symptoms/signs, clinical course and outcomes of people with SCI with symptomatic COVID-19 infections and need for hospitalisation.

Results: Twenty-two people with SCI were included, 15 (68%) were male, median age 64.5 years (interquartile range, IQR, 52-73 years). Nine (41%) had tetraplegia, and eight (36%) were classified with motor-complete lesions. Frequent clinical symptoms were fever (59%), coughing (54%), fatigue (50%), and dyspnoea (27%). Most frequent complications were bacterial pulmonary superinfection (18%), and acute respiratory distress syndrome (18%). Fifteen persons (68%) needed oxygen therapy during the course of hospitalisation, and 7 (32%) people were ventilated. Median length of stay (LOS) was 23 days (IQR 15-35), varying by age for people under 60 years with a median LOS of 9 days (IQR 8-27), and for those older than 60 years with a median of 34 days (IQR 17-39), respectively. In total, 3 persons (14%) died during hospitalisation, all older with paraplegia.

Conclusions: Typical symptoms like fever and coughing were not present in all people. People with tetraplegia did not demonstrate worse outcomes, on the contrary, they had shorter LOS, no difference in ventilation needs, and no higher mortality compared to people with paraplegia. Older people showed longer LOS. This study recommends close supervision of the SCI population to detect early signs and symptoms of COVID-19 infection.

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来源期刊
Spinal Cord Series and Cases
Spinal Cord Series and Cases Medicine-Neurology (clinical)
CiteScore
2.20
自引率
8.30%
发文量
92
期刊最新文献
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