嗜酸性粒细胞是丝虫感染期间 IL-4 的内源性来源,有助于形成最佳的 T 辅助细胞 2 反应。

IF 4.7 3区 医学 Q2 IMMUNOLOGY Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-02-26 DOI:10.1159/000536357
Cécile Guth, Pia Philippa Schumacher, Archena Vijayakumar, Hannah Borgmann, Helene Balles, Marianne Koschel, Frederic Risch, Benjamin Lenz, Achim Hoerauf, Marc P Hübner, Jesuthas Ajendra
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引用次数: 0

摘要

白细胞介素-4(IL-4)是第二类免疫的核心调节因子,对防御蠕虫等多细胞寄生虫至关重要。本研究的重点是它在丝虫感染(人类丝虫感染的模型)过程中的作用和细胞来源。我们的研究发现,嗜酸性粒细胞是 IL-4 的主要来源,尤其是在丝虫感染的早期阶段。我们利用缺乏嗜酸性粒细胞和随后嗜酸性粒细胞衍生的IL-4的dblGATA小鼠,揭示了它们对Th2反应的深刻影响。缺乏嗜酸性粒细胞会影响 Th2 极化,并导致 2 型细胞因子生成受损。令人惊讶的是,嗜酸性粒细胞的缺乏对巨噬细胞的极化和增殖以及抗体的产生没有影响。这些发现为丝虫感染中的IL-4动态和嗜酸性粒细胞效应功能提供了新的线索。
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Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response.

Introduction: Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model for human filarial infections.

Methods: Utilizing an IL-4 secretion assay, investigation into the sources of IL-4 during the progression of L. sigmodontis infection was conducted. The impact of eosinophils on the Th2 response was investigated through experiments involving dblGATA mice, which lack eosinophils and, consequently, eosinophil-derived IL-4.

Results: The absence of eosinophils notably influenced Th2 polarization, leading to impaired production of type 2 cytokines. Interestingly, despite this eosinophil deficiency, macrophage polarization, proliferation, and antibody production remained unaffected.

Conclusion: Our research uncovers eosinophils as a major source of IL-4, especially during the early phase of filarial infection. Consequently, these findings shed new light on IL-4 dynamics and eosinophil effector functions in filarial infections.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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