Mohammad Taheri, Ali Bahrami, Kiana Kimiaei Asadi, Mojdeh Mohammadi, Pejman Molaei, Mehrdad Hashemi, Fatemeh Nouri
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引用次数: 0
摘要
神经元死亡、神经递质活性降低或功能障碍是阿尔茨海默氏症、帕金森氏症和多发性硬化症等神经退行性疾病的部分病理生理学原因。此外，有证据表明感染和传染性病原体在神经退行性疾病中的作用，以及微生物中的某些代谢物在这些疾病的病理生理学中的影响。在本研究中，我们打算对现有的关于感染病原体及其代谢物对神经退行性疾病病理生理学的作用的研究进行评估。我们检索了 PubMed、Scopus、Google Scholar 和 Web of Science 等搜索引擎。在神经退行性疾病中发现了一些感染性病原体。此外，分离出的一些真菌和微藻对帕金森氏症和阿尔茨海默氏症也有改善作用。
A review on nonviral, nonbacterial infectious agents toxicity involved in neurodegenerative diseases.
Neuronal death, decreased activity or dysfunction of neurotransmitters are some of the pathophysiological reasons for neurodegenerative diseases like Alzheimer's, Parkinson's and multiple sclerosis. Also, there is evidence for the role of infections and infectious agents in neurodegenerative diseases and the effect of some metabolites in microorganisms in the pathophysiology of these diseases. In this study, we intend to evaluate the existing studies on the role of infectious agents and their metabolites on the pathophysiology of neurodegenerative diseases. PubMed, Scopus, Google Scholar and Web of Science search engines were searched. Some infectious agents have been observed in neurodegenerative diseases. Also, isolations of some fungi and microalgae have an improving effect on Parkinson's and Alzheimer's.
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