虚弱对心衰预后的影响:与性别有关吗?

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI:10.1007/s11897-024-00650-4
Lara Aguilar-Iglesias, Ana Perez-Asensio, Lidia Vilches-Miguel, Cesar Jimenez-Mendez, Pablo Diez-Villanueva, Jose-Angel Perez-Rivera
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引用次数: 0

摘要

审查目的:心力衰竭(HF)是导致老年患者入院的最常见原因之一,尤其是女性患者,她们患有老年综合征(如虚弱)的比例很高。研究表明,虚弱及其影响在男性和女性之间也可能存在差异。因此,了解虚弱如何因性别不同而对高血压患者产生不同影响,对于提供个性化护理至关重要。本综述旨在总结性别对高血压患者虚弱预后影响的作用:大量研究发现,虚弱是全因死亡率和再入院率的重要预测因素。最近一项针对老年心房颤动门诊患者的研究表明,虽然女性的体弱发生率较高,但只有男性的体弱才是死亡率和再入院率的独立预测因素。此外,另一项研究显示,身体虚弱与男性首次发生临床事件的时间有关,但与女性无关。这些结果提出了一个问题:为什么虚弱会对男性和女性的心房颤动预后产生不同的影响?女性心房颤动患者体弱的发生率更高,尤其是当体弱被视为身体机能下降时。然而,虚弱对男性和女性心房颤动预后的影响是不同的。女性心房颤动患者的死亡率低于男性,只有男性的预后与体弱有关。男女之间心房颤动的严重程度不同,以及其他荷尔蒙、社会心理和临床因素都可能与这一事实有关。
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Impact of Frailty on Heart Failure Prognosis: Is Sex Relevant?

Purpose of review: Heart failure (HF) is one of the most frequent causes of hospital admission in elderly patients, especially in women, who present a high prevalence of geriatric syndromes like frailty. Studies have suggested that frailty and its impact may also differ between males and females. Understanding how frailty may differently affect HF patients depending on sex is therefore imperative for providing personalized care. The aim of this review is to summarize the role of sex in the prognostic impact of frailty in HF patients.

Recent findings: Numerous studies have identified frailty as a significant predictor of all-cause mortality and hospital readmissions. A recent study of elderly HF out-patients demonstrated that while women had a higher prevalence of frailty, it was an independent predictor of mortality and readmission only in men. Moreover, another study revealed that physical frailty was associated with time to first clinical event among men but not among women. These results raise the question about why frailty affects differently HF prognosis in men and women. Women with HF present a higher prevalence of frailty, especially when it is considered as physical decline. Nevertheless, frailty affects differently HF prognosis in men and women. Women with HF present lower mortality than men and frailty is related with prognosis only in men. The different severity of HF between men and women and other hormonal, psychosocial, and clinical factors might be involved in this fact.

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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
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