Research Progress on the Application of Nanocellulose in Glucose Sensing.

Background: Nanocellulose is not only a biocompatible and environmentally friendly material but also has excellent mechanical properties, biodegradability, and a large number of hydroxyl groups that have a strong affinity for water. These characteristics have attracted significant attention from researchers in the field of glucose sensing.

Objective: This review provides a brief overview of the current research status of traditional materials used in glucose sensors. The sensing performance, chemical stability, and environ-mental properties of nanocellulose-based glucose sensors are compared and summarized based on the three sensing methods: electrochemical sensing, colorimetric sensing, and fluo-rescence sensing. The article focuses on recent strategies for glucose sensing using nanocel-lulose as a matrix. The development prospects of nanocellulose-based glucose sensors are also discussed.

Conclusion: Nanocellulose has outstanding structural characteristics that contribute signifi-cantly to the sensing performance of glucose sensors in different detection modes. However, the preparation process for high-quality nanocellulose is complicated and has a low yield. Furthermore, the sensitivity and selectivity of nanocellulose-based glucose sensors require further improvement.