儿童 13 价肺炎球菌结合疫苗 (PCV13) 对加拿大老年人的间接影响:加拿大免疫研究网络 (CIRN) 的一项回顾性观察研究。

IF 9 1区 医学 Q1 RESPIRATORY SYSTEM Thorax Pub Date : 2024-08-19 DOI:10.1136/thorax-2023-220377
Sharifa Nasreen, Jun Wang, Fawziah Marra, Jeffrey C Kwong, Allison McGeer, Manish Sadarangani, Sarah E Wilson, Shaza A Fadel
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引用次数: 0

摘要

背景:自 2010 年以来,13 价肺炎球菌结合疫苗 (PCV13) 已成为安大略省和不列颠哥伦比亚省 (BC) 公共资助的儿童免疫计划的一部分。我们通过一项回顾性观察研究评估了婴儿 PCV13 计划对老年人(年龄≥65 岁)侵袭性肺炎球菌疾病(IPD)和全因肺炎住院的间接影响:我们从实验室和卫生行政数据库中提取了2005年1月至2018年12月期间的每月IPD和全因肺炎病例。我们采用准实验差分设计,以 2010 年之前(PCV13 之前)和之后(PCV13 之后)的 IPD 或全因肺炎病例发病率计算风险比(RRR),并以骨折率作为对照:结果:在儿童 PCV13 计划实施后的 8 年中,安大略省和不列颠哥伦比亚省老年人的所有 IPD 或 PCV 血清型特异性 IPD 发病率均未发生变化。安大略省的全因肺炎率有所上升(RRR 1.38,95% CI 1.11 至 1.71),但不列颠哥伦比亚省的全因肺炎率保持不变:尽管加拿大两个省份的儿童 PCV13 疫苗接种计划已经成熟,但社区对老年人免于因肺炎球菌疾病住院的间接保护却停滞不前。
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Indirect impact of childhood 13-valent pneumococcal conjugate vaccine (PCV13) in Canadian older adults: a Canadian Immunization Research Network (CIRN) retrospective observational study.

Background: 13-valent pneumococcal conjugate vaccine (PCV13) has been part of publicly funded childhood immunisation programmes in Ontario and British Columbia (BC) since 2010. We assessed the indirect impact of infant PCV13 programmes on invasive pneumococcal disease (IPD) and all-cause pneumonia hospitalisation in older adults (aged ≥65 years) using a retrospective observational study.

Methods: We extracted monthly IPD and all-cause pneumonia cases from laboratory and health administrative databases between January 2005 and December 2018. Using a quasi-experimental difference-in-differences design, we calculated the ratio of risk ratios (RRRs) using incidence rates of IPD or all-cause pneumonia cases before (pre-PCV13 period) and after (PCV13 period) 2010 with rates of fractures as controls.

Results: The rates of all IPD or PCV serotype-specific IPD for older adults in both Ontario and BC did not change in 8 years after childhood PCV13 programme implementation. All-cause pneumonia increased in Ontario (RRR 1.38, 95% CI 1.11 to 1.71) but remained unchanged in BC.

Conclusions: Indirect community protection of older adults from hospitalisation with pneumococcal disease stalled despite maturation of childhood PCV13 vaccination programmes in two Canadian provinces.

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来源期刊
Thorax
Thorax 医学-呼吸系统
CiteScore
16.10
自引率
2.00%
发文量
197
审稿时长
1 months
期刊介绍: Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.
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