Imamhusen Jamadar , Athmanand Anchi , Shruti S. Malunavar , Rajesh G. Kalkhambkar , Suraj M. Sutar , Shrinivas D. Joshi
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引用次数: 0
摘要
在此，我们介绍了以[BMIM]-IL 为可重复使用溶剂的 Pd 催化声化学反应，从 2,2′-二溴二苯基合成各种咔唑支架。在[PAIM][NTf2]的存在下，多种伯胺被用作偶联剂，[PAIM][NTf2]在离子液体介质中表现出强大的促进作用，从而避免了对有害挥发性有机化合物的需求。离子液体的可回收性突出了该反应的绿色方法。此外，还对合成的咔唑支架进行了抗菌活性评估。发现化合物 3e 和 3g 具有很高的活性。通过计算机模拟与目标蛋白质对接的方法，筛选出了这些支架最可能的结合位点。
Ionic liquid Mediated Pd-catalyzed sonochemistry for facile synthesis of carbazoles: Molecular Modelling and antimicrobial studies
Herein we have described the Pd-catalyzed sonochemistry driven by [BMIM]-IL as re-useable solvent to synthesize various carbazole scaffolds from 2,2′-dibromodiphenyl. Diverse primary amines were utilised as coupling partners in the presence of [PAIM][NTf2], which exhibits an impactful promoter in the IL medium, thereby avoiding the need for hazardous VOC's. The recyclability of ionic liquids highlights the green approach of the reaction. Further, the synthesized carbazole scaffolds were assessed for antimicrobial activity. Compounds 3e and 3g are found to be highly active. The most probable binding sites for these scaffolds were screened through a computer-simulated docking method with targeted protein.
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